- Process for the preparation of certain substituted aromatic compounds
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The present invention involves process for the preparation of compounds having the chemical structure: STR1 wherein Ar--H is an aromatic compound which is activated to an electrophilic attack, and wherein --Y is an aliphatic group having a labile moiety,
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- Tert-butylphenyl compounds useful as anti-inflammatory agents
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The present invention involves compounds having the structure: STR1 wherein: (a) --A1 is selected from the group consisting of --OH, --H, and --O2 CR; (b) --A2 is selected from the group consisting of unsubstituted or substituted, saturated or unsaturated, straight, branched and cyclic alkyl having from 1 to about 10 carbon atoms; (c)--A3 is selected from --C(CH3)3, --Si(CH3)3, and --CF3 ; and (d) --Y is selected from certain low molecular weight alkyl chains which terminate in specific unsaturated functional groups: STR2 and aldehydes in the form of their acetals; pharmaceutical compositions comprising such compounds; and methods for treating inflammation by administering such compounds.
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