- INFANT FORMULA CONTAINING AN AROMA COMPOSITION FOR USE AS FRAGRANCE
-
The invention relates to a nutraceutical composition such as infant formula or infant food comprising a) a defined aroma composition; b) a methodology for developing, maintaining certain aroma constituents in the infant formula and an aroma or fragrance composition to be used to increase the acceptance of a person or an object by the baby or new born.
- -
-
-
- Structure-Activity Studies with the αβ-Dihydroxyacid Dehydratase of Salmonella typhimurium
-
(2RS,3RS)- and (2RS,3SR)-2,3-Dihydroxybutanoic acids, (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid, (2RS)-2-ethyl-2,3-dihydroxypentanoic acid, (2RS,3RS)- and (2RS,3SR)-2,3-dihydroxy-3-methylhexanoic acids, and (2RS,3RS)- and (2RS,3SR)-2,3-dihydroxy-3-methylheptanoic acids were synthesised.These acids, as well as (RS)-2,3-dihydroxy-3-methylbutanoic acid and (RS)-glyceric acid were tested as substrates for the αβ-dihydroxyacid dehydratase of the isoleucine-valine biosynthetic pathway of Salmonella typhimurium.For acids having a propyl group at C-3, the activities were greatly reduced compared with those obtained for the natural substrates (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid and (R)-2,3-dihydroxy-3-methylbutanoic acid .For acids having an n-butyl substituent at C-3, the activities were close to zero. (2RS,3SR)-2,3-Dihydroxybutanoic acid (threo isomer) underwent dehydration at a rate comparable with that of (2R,3R)-DHI, the natural substrate in the isoleucine pathway, whereas the (2RS,3RS)-acid (erythro-isomer) had much lower activity and (RS)-glyceric acid had even less activity.These results illustrate differences in the alkyl group requirements with respect to the areas of the binding site of the enzyme that accomodate the C-3 substituents.They also demonstrate the size limits of the alkyl groups that can be accomodated in substrate analogues.
- Armstrong, Frank B.,Lipscomb, Elizabeth L.,Crout, David H. G.,Morgan, Phillip J.
-
p. 691 - 696
(2007/10/02)
-
- Synthesis of isoprenoid 1,5-dienes
-
Aliphatic acids containing an isoprenoid 1,5-diene moiety are prepared in high yields by the selective gamma alkylation of α,β-unsaturated acids with allylic electrophiles. The gamma-regioselectivity of the alkylation is controlled by the use of the dicopper(I) dienolates prepared from the α,β-unsaturated acids. The method offers a particularly facile means for synthesizing isoprenoid 1,5-diene natural products such as farnesoic acid by alkylation of senecioic acid with geranyl bromide; geranoic acid by alkylation of senecioic acid with 3,3-dimethallyl bromide; and dl-lanceol by alkylation of tiglic acid with an allylic bromide derived from dl-limonene. Such products find use in the synthesis of insect pheremones, insect juvenile hormones, and components of perfumes.
- -
-
-