- Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives
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A series of 1,4-phenylene-bis-chalcones 3a{3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a{5h were obtained by the addition of guanidine hy
- Gürdere, Meliha Burcu,Kamo, Erdo?an,?ahin Ya?lio?lu, Ay?e,Budak, Yakup,Ceylan, Mustafa
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- Aluminum chloride-catalyzed C-alkylation of pyrrole and indole with chalcone and bis-chalcone derivatives
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The AlCl3-catalyzed alkylation of pyrrole (2) with chalcone (1a-i) at a ratio of 8:1 in the presence of 10 mol% AlCl3 gave the solely 2-alkyl pyrroles (3a-i) at room temperature for 12 in good yields. The same reaction was performed with pyrrole (2) and chalcone at a ratio of 1:3 in CH3CN at rt for 3 h to achieve 2,5-dialkyl pyrroles (4a-f). In addition, the reaction of the pyrrole (2) and indole (7) on 1,4-phenylene bis-chalcones (5a-g) at the ratio of 8:1 at rt for 24 h gave the double-addition products 6a-g and 8a-g in good yields, respectively. The structure of the products was confirmed by 1H and 13C NMR spectroscopy and elemental analysis.
- Gürdere, Meliha Burcu,?zbek, Oguz,Ceylan, Mustafa
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supporting information
p. 322 - 331
(2016/03/23)
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- Study of 1,3-dipolar cycloaddition and ring contraction of new 1,4-phenylene-bis[1,5]benzothiazepine derivatives
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Some 1,4-phenylene-bis[1,2,4]oxadiazolo-[5,4-d][1,5]benzothiazepine derivatives (4a-c) were synthesized by 1,3-dipolar cycloaddition reaction of benzohydroximinoyl chloride with 1,4-phenylene-bis(4-aryl)- 2,3-dihydro[1,5]benzothiazepine (2a-c); meanwhile,
- Chen, Fei,Liu, Fang-Ming,Dong, Zhi-Qiang
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p. 1764 - 1769
(2015/01/09)
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- 'One-pot' ultrasound irradiation promoted synthesis and spectral characterization of an array of novel 1,1′-(5,5′-(1,4-phenylene) bis(3-aryl-1H-pyrazole-5,1(4H,5H)-diyl))diethanones, a bis acetylated pyrazoles derivatives
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An array of novel 1,1′-(5,5′-(1,4-phenylene)bis(3-aryl-1H- pyrazole-5,1(4H,5H)-diyl))diethanones, a bis acetylated pyrazoles derivatives are synthesized in 'one-pot' by ultrasound irradiation method and are characterized by melting point, elemental analys
- Kanagarajan,Ezhilarasi,Gopalakrishnan
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scheme or table
p. 635 - 639
(2011/03/16)
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- Synthesis and in vitro microbiological evaluation of novel diethyl 6,6′-(1,4-phenylene)bis(4-aryl-2-oxo-cyclohex-3-enecarboxylates)
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Novel bis cyclohexenone ester derivatives 1419 were synthesized and characterized by their spectral data. In vitro microbiological evaluations were carried out for all the novel compounds 1419 against clinically isolated bacterial and fungal strains. Comp
- Kanagarajan,Ezhilarasi,Gopalakrishnan
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scheme or table
p. 498 - 505
(2012/05/19)
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- A facile synthesis of 1,4-bis-(3-Aryl-3-oxo-1-propenyl)benzenes under microwave irradiation
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1,4-bis(3-Aryl-3-oxo-1-propenyl)benzenes were synthesized by 1,4-benzenedicarboxaldehyde with substituted acetophenones in the presence of sodium hydroxide under microwave irradiation with good yields.
- Zhou, Jian-Feng,Zhou, Jun-Feng,Zou, Zheng-Cai,Feng, Jun-Cai
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p. 3389 - 3392
(2007/10/03)
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