cas 2509-18-4, 4-(4-FORMYLPHENOXY)BENZOIC ACID | Articles data ｜lookchem

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2509-18-4

Articles about 2509-18-4Total 2 be found

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Discovery of orally available spirodiketopiperazine-based CCR5 antagonists
Using the previously reported novel spirodiketopiperazine scaffold, the design and synthesis of orally available CCR5 antagonists was undertaken. Compounds possessing a carboxylic acid function in the appropriate position showed improved oral exposure (AU
Nishizawa, Rena,Nishiyama, Toshihiko,Hisaichi, Katsuya,Hirai, Keisuke,Habashita, Hiromu,Takaoka, Yoshikazu,Tada, Hideaki,Sagawa, Kenji,Shibayama, Shiro,Maeda, Kenji,Mitsuya, Hiroaki,Nakai, Hisao,Fukushima, Daikichi,Toda, Masaaki
experimental part
p. 5208 - 5223
(2010/09/18)

PYRROLIDINE DERIVATIVE OR SALT THEREOF
[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).
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Page/Page column 46-47

(2008/06/13)

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Chemical Properties

Melting Point: 170-173 °C(Solv: dichloromethane (75-09-2); ligroine (8032-32-4))
Boiling Point: 429.565 °C at 760 mmHg
Flash Point:166.637 °C
Density: 1.315 g/cm³
PKA: 4.24±0.10(Predicted)
PSA: 63.60000
LogP: 2.98960

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