- Synthetic method N - cyanoethyl imidazole compound
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The N - cyanoethyl imidazole compound is prepared from imidazoles and derivatives thereof as raw materials and acrylonitrile as Michael addition acceptors, and is free of catalysts. The N - cyanoethyl imidazole compound is synthesized in a solvent-free and air atmosphere at a high yield in a one-step method. The method is simple to operate, environmentally friendly, economical and practical, stable in performance and wide in product market. The reaction does not need special post-treatment, no by-product is generated, and the method is suitable for industrial production.
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Paragraph 0040-0042
(2021/10/16)
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- Efficient protocol for Aza-Michael addition of N-heterocycles to α,β-unsaturated compound using [Ch]OH and [n-butyl urotropinium]OH as basic ionic liquids in aqueous/solvent free conditions
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The present work emphasizes on a green methodology using designed and synthesized basic ionic liquid, [n-butyl Urotropinium]OH, and commercially available aqueous solution of choline hydroxide [Ch]OH as catalysts for executing Aza-Michael addition of N-heterocycles to α,β-unsaturated compounds at room temperature. The highlighting features of these catalysts include using low concentration of both catalysts along with [Ch]OH being low cost and biodegradable, [n-butyl Urotropinium]OH significantly enhancing the high substrate/catalyst ratio to obtain the desired products in high yield and purity in most cases. Further, both catalysts were recyclable and recoverable up to five cycles.
- Kumar, Sitanshu,Kaur, Amanpreet,Singh, Vasundhara
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p. 193 - 201
(2019/01/24)
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