- An efficient synthesis of 5-chloro-2, 3, 4-trifluorobenzoic acid
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5-Chloro-2, 3, 4-trifluorobenzoic acid, a key intermediate for preparing quinolone-3-carboxylic acid derivatives, was synthesised from the commercially available 2, 3, 4, 5-trifluorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.
- Yu, Shuitao,Zhou, Weiyou,Xia, Zhengjun,Lin, Song,Chen, Zaixin
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p. 326 - 327
(2015/08/18)
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- Trifluoro-substituted benzoic acid, esters thereof, and process for producing the same
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The present invention is to provide a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid, esters thereof, which are useful as a starting material for synthesizing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.
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