- Flavonoids as vasorelaxant agents: Synthesis, biological evaluation and quantitative structure activities relationship (QSAR) studies
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A series of 2-(2-diethylamino)-ethoxychalcone and 6-prenyl(or its isomers)-flavanones 10a,b and 11a-g were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pretreated with 1 μM phenylephrine (PE). Several compounds showe
- Dong, Xiaowu,Wang, Yanming,Liu, Tao,Wu, Peng,Gao, Jiadi,Xu, Jianchao,Yang, Bo,Hu, Yongzhou
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p. 8257 - 8272
(2011/12/15)
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- Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei
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Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.
- Sugamoto, Kazuhiro,Matsusita, Yoh-Ichi,Matsui, Kana,Kurogi, Chiaki,Matsui, Takanao
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p. 5346 - 5359
(2011/08/04)
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- Synthesis of four natural prenylflavonoids and their estrogen-like activities
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Four prenylflavonoids, bavachin 1, isobavachin 2, 7,4′-dihydroxy-8- prenylflavone 3, and 8-prenylapigenin 4 were synthesized and recognized for possessing estrogen-like activity in MCF-7/BOS cells, as evaluated by an estrogen-screening assay. All compound
- Dong, Xiaowu,Fan, Yongjian,Yu, Lingjun,Hu, Yongzhou
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p. 372 - 376
(2008/02/11)
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- New Syntheses of 4',7-Dihydroxy-6,8-di-C-prenylflavanone, Bavachin, Isobavachin and Related Compounds
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The titel compounds have been synthesised by nuclear prenylation of 4',7-dihydroxyflavanone(liquiritigenin, III), Cyclodehydrogenation of bavachin and isobavachin with DDQ yields the chromenoflavanones (VIII) and (X) respectively which on dehydrogenation
- Krishnamurti, M.,Parthasarathi, J.
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p. 247 - 248
(2007/10/02)
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