Diastereomeric resolution of racemic o-chloromandelic acid
The separation of rac-o-chloromandelic acid 1 with enantiopure aryloxypropylamine via diastereomeric salt formation was investigated. (R)-o-chloromandelic acid (R)-1, a key intermediate for the antithrombotic agent clopidogrel, was obtained in 65% yield a
A convenient synthesis of the novel hypoglycemic agent SDZ PGU 693
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Desai
p. 4939 - 4940
(2007/10/03)
Bicyclic oxazole and thiazole substituted ethers
The invention concerns oxazole and thiazole compounds of formula where the substituents have various significances, in free form or salt form as appropriate. They can be prepared e.g. by coupling or hydrolysis. The compounds can be used as pharmaceuticals, especially as hypoglycemic agents in the treatment of diabetes.
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(2008/06/13)
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