cas 16713-66-9, Cyclopentane-1,1-diacetic acid | Articles data ｜lookchem

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16713-66-9

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Antiproliferative and antibacterial activity of some glutarimide derivatives
Antiproliferative and antibacterial activities of nine glutarimide derivatives (1–9) were reported. Cytotoxicity of compounds was tested toward three human cancer cell lines, HeLa, K562 and MDA-MB-453 by MTT assay. Compound 7 (2-benzyl-2-azaspiro[5.11]heptadecane-1,3,7-trione), containing 12-membered ketone ring, was found to be the most potent toward all tested cell lines (IC50 = 9–27 μM). Preliminary screening of antibacterial activity by a disk diffusion method showed that Gram-positive bacteria were more susceptible to the tested compounds than Gram-negative bacteria. Minimum inhibitory concentration (MIC) determined by a broth microdilution method confirmed that compounds 1, 2, 4, 6–8 and 9 inhibited the growth of all tested Gram-positive and some of the Gram-negative bacteria. The best antibacterial potential was achieved with compound 9 (ethyl 4-(1-benzyl-2,6-dioxopiperidin-3-yl)butanoate) against Bacillus cereus (MIC 0.625 mg/mL; 1.97 × 10?3mol/L). Distinction between more and less active/inactive compounds was assessed from the pharmacophoric patterns obtained by molecular interaction fields.
Popovi?-Djordjevi?, Jelena B.,Klaus, Anita S.,?i?ak, ?eljko S.,Mati?, Ivana Z.,Drakuli?, Branko J.
p. 915 - 923
(2016/10/09)

APOPTOSIS INDUCERS
This invention comprises novel compounds which inhibit the activity of anti-apoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases involving a defect in apoptosis, such as, for example, in the treatment of cancer.
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(2014/01/08)

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Chemical Properties

Appearance/Colour :White powder.
Melting Point: 180-181 ºC
Boiling Point: 396.2°Cat760mmHg
Flash Point:207.6°C
Density: 1.228g/cm³
Solubility:within almost transparency in Methanol
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 2.21E-07mmHg at 25°C
Refractive Index: 1.4129 (estimate)
PKA: 4.42±0.10(Predicted)
BRN: 2099523
PSA: 74.60000
LogP: 1.49620

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