- Copper-catalyzed synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles via [3+2] cycloadditions of hydrazones and nitroolefins
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A highly economical and efficient copper(I)-catalyzed regioselective method for the synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles via [3+2] cycloaddition of hydrazones and nitroolefins has been reported. This process displays excellent applicability with a wide range of substrates under mild conditions.
- Shi, Chong,Ma, Chaowei,Ma, Haojie,Zhou, Xiaoqiang,Cao, Jinhui,Fan, Yuxing,Huang, Guosheng
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p. 4055 - 4058
(2016/07/06)
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- Synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines via cascade imination/intramolecular decarboxylative coupling
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A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines is described involving the implementation of a cascade imination/intramolecular decarboxylative coupling between potassium 2-amino(hetero)benzoates and 2-haloarylaldehydes. The reactions of pyrazole-based substrates require a Pd-Cu bimetallic system for superior yields whereas the thienyl-based substrates afford the products in excellent yields with a Pd-catalyst only.
- Pandey, Garima,Bhowmik, Subhendu,Batra, Sanjay
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supporting information
p. 5044 - 5047
(2013/10/22)
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- Cu(OAc)2·H2O-catalyzed N-arylation of nitrogen-containing heterocycles
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In the absence of any additional ligands, the efficient N-arylation of nitrogen-containing heterocycles with aryl iodides catalyzed by relative low catalyst amount of Cu(OAc)2·H2O was developed. This simple catalytic system is involved in the C-N cross-coupling reaction and works for a variety of pyrazole, pyrrole, imidazole, triazole, indole, benzoimidazole, benzotriazole, carbazole, and anilines as well as aryl iodides with different electronic properties. Highly efficient copper(II)-catalyzed N-arylation protocol was established.
- Xu, Zhong-Lin,Li, Hong-Xi,Ren, Zhi-Gang,Du, Wei-Yuan,Xu, Wei-Chang,Lang, Jian-Ping
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supporting information; experimental part
p. 5282 - 5288
(2011/08/04)
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- Regioselective rapid analog synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling
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Regioselective routes for the synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling of 4-bromo (or 4-iodo)-1,3-(or 1,5-)diphenyl-5-(or 3-)(methylthio)pyrazoles have been reported.
- Khan, Taukeer A.,Kumar, Sarvesh,Venkatesh, Chelvam,Ila, Hiriyakkanavar
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p. 2961 - 2968
(2011/05/05)
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- Pd-catalyzed cross-coupling reactions of halogenated 1-phenylpyrazol-3-ols and related triflates
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1-Phenyl-1H-pyrazol-3-ol was used as a versatile synthon for the preparation of various 1-phenyl-1H-pyrazole derivatives substituted at C-3 and C-4 of the pyrazole nucleus and at the phenyl ring para-position. Treatment of 1-phenyl-1H-pyrazol-3-ol with tr
- Arba?iauskiene, Egle,Vilkauskaite, Gyte,Eller, Gernot A.,Holzer, Wolfgang,?a?kus, Algirdas
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experimental part
p. 7817 - 7824
(2009/12/26)
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- Regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio) pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles
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Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/ annulated-5-(methylthio)-pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/ annulated pyrazoles has been reported via cyclocondensation of arylhydrazines with either α-oxoketene dithioacetals or β-oxodithioesters.
- Peruncheralathan,Khan,Ila,Junjappa
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p. 10030 - 10035
(2007/10/03)
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- REPLACEMENT OF DIPOLAROPHILE OF 1,3-CYCLOADDUCT
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Novel double 1,3-cycloreversion and the replacement of dipolarophile of the bisadducts of 3-phenyl sydnone and N-phenylmaleimide are described.
- Sun, Kwok Kun
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p. 321 - 322
(2007/10/02)
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