Strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines: Application to the CCR3 antagonist IS811
A strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines is proposed and applied to the preparation of IS811, a potent CCR3 antagonist. The C2 stereocenter is derived from commercial (R)-epichlorohydrin, while the C4 stereocent
Kauffman, Goss S.,Watson, Paul S.,Nugent, William A.
p. 8975 - 8977
(2007/10/03)
Substituted silyl alkylene amines
This invention relates to substituted silyl alkylene amines, to the intermediates and processes useful for their preparation, to their pharmacological use as MAO-B inhibitors and to their end-use application in the treatment of Parkinson's Disease and senile dementia of Alzheimer's type.
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(2008/06/13)
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