- PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS
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A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.
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- CARRIER-LINKED PROSTANOID PRODRUGS
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The present invention relates to carrier-linked prostanoid prodrugs of formula (I) Z1 -(X0 - L0 - PG0)y (I), wherein Z1, X0, L0, PG0 and y have the meaning as indicated in the description and claims; pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising the same. It further relates to their use as medicaments, especially for treating, controlling, delaying or preventing pulmonary arterial hypertension.
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