- SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS
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Compounds of the general formula:processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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Page/Page column 96; 97
(2018/05/29)
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- Novel tetranuclear triarylantimony(v) complexes with (±)-mandelic acid ligands: Synthesis, characterization, in vitro cytotoxicity and DNA binding properties
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Four novel tetranuclear organoantimony(v) complexes [R3SbL] 4, in which LH = (±)-mandelic acid and R = phenyl (1), 4-fluorophenyl (2), 3-fluorophenyl (3), 3,4,5-trifluorophenyl (4), were synthesized and characterized. The complexes displayed rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells and efficient CT-DNA binding.
- Jiang, Jin,Yin, Handong,Wang, Fangli,Han, Zhong,Wang, Fei,Cheng, Shuang,Hong, Min
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supporting information
p. 8563 - 8566
(2013/07/27)
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- Method for Producing 2-aminobiphenylene
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The present invention relates to a process for preparing 2-aminobiphenyls of the formula I in which n is 0, 1, 2 or 3,R1 is hydrogen, cyano or fluorine, andeach R2 is independently selected from cyano, fluorine, C1-C4
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Page/Page column 8
(2011/12/14)
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- Prodrug of cinnamide compound
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The present invention provides a most suitable prodrug of a cinnamide compound. The prodrug is represented by Formula (I) wherein Ra and Rb each denote a C1-6 alkyl group or the like; Xa denotes a methoxy group or a fluorine atom; Y denotes a phosphono group or the like; and A denotes a cyclic lactam derivative.
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Page/Page column 67; 71
(2009/03/07)
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- TWO CYCLIC OXOMORPHORIN DERIVATIVES
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The present invention relates to a compound represented by formula (I): wherein R1 represents a C1-3 alkyl group, R2 represents a hydrogen atom or a C1-3 alkyl group, Ar represents a phenyl group or the like which may be substituted with 1 to 3 substituents, X represents an oxygen atom or the like, n and m are the same or different and integers of 0 to 2, or a pharmacologically acceptable salt, and use thereof as a medicament.
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Page/Page column 21-22; 34
(2008/12/08)
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- Process for the preparation of fluorophenylalkylene acid derivatives
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The invention relates to the preparation of fluorophenylalkylene acid derivatives of the formulae (4-1)-(4-3): by reaction between fluoroarylmetal halides of formulae (1-1) or (1-2) with carboxylic acid derivatives of formulae (2-1)-(2-3): in the presence
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