cas 144750-42-5, CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) | Articles data ｜lookchem

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144750-42-5

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Synthesis and characterization of impurity B of S-(+)-clopidogrel bisulfate: An antiplatelet
S-(+)-Clopidogrel bisulfate [(S-(+)-methyl 2-(2-chlorophenyl)-2-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-yl)acetate bisulfate)] is a platelet aggregation inhibitor drug. S-(+)-Clopidogrel bisulfate is prepared by different synthetic approaches in the literature. In almost all the approaches the major impurities known in the literature (A, B, and C) are also listed in the U.S. pharmacopoeia. The control of these pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this article, a description of these impurities and their origins in the S-(+)-clopidogrel bisulfate process are presented along with the preparation of impurity B.
Reddy, K. Tatendra,Kumar, K. Suneel,Omprakash,Dubey
p. 1387 - 1396
(2013/05/22)

Method of Preparing Clopidogrel and Intermediates Used Therein
Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
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Page/Page column 5

(2008/12/08)

PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention relates to a new process for the preparation of clopidogrel and to new polymorphic forms of clopidogrel salts, to processes for their preparation and to a pharmaceutical formulation containing the new forms.
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Page/Page column 51

(2008/06/13)

METHOD OF PREPARING CLOPIDOGREL AND INTERMEDIATES USED THEREIN
Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
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Page/Page column 13

(2010/11/25)

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Chemical Properties

Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Storage Temp.:Inert atmosphere,Room Temperature
PSA: 68.78000
LogP: 4.32540

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