- Preparation method of 3-amino-4-chlorobenzoic acid hexadecyl ester
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The invention provides a preparation method of 3-amino-4-chlorobenzoic acid hexadecyl ester. The preparation method comprises the following steps: by taking p-chlorobenzoic acid as an initial raw material, firstly carrying out acylating chlorination reaction on p-chlorobenzoic acid, DMF (Dimethyl Formamide) and a chlorination reagent to generate p-chlorobenzoyl chloride; then carrying out esterification reaction with hexadecanol to generate hexadecyl p-chlorobenzoate; then carrying out nitration reaction with sulfuric acid and nitric acid to generate 3-nitro-4-chlorobenzoic acid hexadecyl ester; and finally, carrying out a reduction reaction with hydrogen under the catalysis of raney nickel to generate the 3-amino-4-chlorobenzoic acid hexadecyl ester. The preparation method disclosed by the invention is high in yield, high in product purity and low in cost.
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Paragraph 0039; 0043; 0047; 0051
(2021/01/28)
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- Preparation method for 3-amino-4-hexadecyl chlorobenzoate
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The invention relates to a preparation method for 3-amino-4-hexadecyl chlorobenzoate. The method comprises the following steps: adding 3-amino-4-chlorobenzoic acid and n-hexadecanol into a water-carrying agent, carrying out heating to 50 DEG C, maintaining a constant temperature for 0.5 to 1 h, then adding a catalyst namely p-toluenesulfonic acid, continuing heating to 140 to 170 DEG C, carrying out a reaction under a refluxing state for 6 to 12 h, and stopping heating; adding an organic solvent into a reaction solution obtained in the previous step, then carrying out cooling crystallization,washing and filtering, and drying a filter cake so as to obtain a crude product; collecting a filtrate; adding an organic solvent into the crude product, carrying out dissolving under heating, and carrying out cooling crystallization and filtering; and drying a filter cake so as to obtain a finished product namely the 3-amino-4-hexadecyl chlorobenzoate. The preparation method provided by the invention improves the utilization rate of raw materials, improves the yield of a product, reduces the treatment amount of an industrial filtrate, reduces the cost of industrial production and is more favorable for industrial production.
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Paragraph 0030-0038
(2019/10/01)
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- Process for preparing esters of 3-amino-4-halobenzoic acid
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Disclosed is a process for producing good yields of high quality esters of 3-amino-4-halobenzoic acid by contacting the subject acid with an alkyl halide or sulfonate in a solvent in the presence of an aqueous alkali metal hydroxide and a phase transfer c
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Page/Page column 3
(2008/06/13)
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