- MACROCYCLIC COMPOUNDS
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The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.
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- HISTONE DEMETHYLASE INHIBITORS FOR TREATING CANCERS
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The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyqui
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- MCL-1 INHIBITORS AND METHODS OF USE THEREOF
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Disclosed are Mcl-1 inhibitors, pharmaceutical compositions comprising the same and methods of using the same.
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- An extremely stable and orthogonal DNA base pair with a simplified three-carbon backbone
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A nucleotide C3HQ with a minimal three-carbon backbone displays unprecedented pairing strength and orthogonality in a homopair C3HQ:C3HQ in the presence of one equivalent of Cu2+. The pairing stability in DNA ev
- Zhang, Lilu,Meggers, Eric
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- Preparation and Fungitoxicity of 3,6-Dichloro- and 3,6-Dibromo-8-Quinolinols
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3,6-Dichloro- and 3,6-dibromo-8-quinolinols were prepared by direct halogenation of 8-nitroquinoline by N-halosuccinimide in acetic acid or by halogenation of the corresponding 6-halo-8-nitroquinoline prepared via a Skraup reaction.The nitro group was reduced to amino and the amine was hydrolyzed to the phenol in 70percent sulfuric acid at 220 deg C.The fungitoxicity of 3,6-dichloro- and 3,6-dibromo-8-quinolinols, as well as intermediates in their preparation, against Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor cirinelloides was determined. 3,6-dichloro-8-quinolinol is the most fungitoxic analogue of this class of compounds observed to date. - Keywords. 3,6-dichloro-8-nitroquinoline; 3,6-dibromo-8-nitroquinoline; 8-amino-3,6-dichloroquinoline; 8-amino-3,6-dibromoquinoline; 3,6-dichloro-8-quinolinol; 3,6-dibromo-8-quinolinol; 1H NMR spectra.
- Gershon, H.,Clarke, D. D.,Gershon, M.
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p. 723 - 730
(2007/10/02)
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- Improved Syntheses of Some Monohloro- and Monobromo-8-quinolinols
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Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spetra for the 12 possible monochloro
- Gershon, Herman,Clarke, Donald D.
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p. 935 - 942
(2007/10/02)
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