- Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration
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The post-PKS modification steps of FK506 biosynthesis include C9-oxidation and 31-O-methylation, but the sequence of these reactions and the exact route have remained unclear. This study details the post-PKS modification pathways in FK506 biosynthesis thr
- Ban, Yeon Hee,Shinde, Pramod B.,Hwang, Jae-Yeon,Song, Myoung-Chong,Kim, Dong Hwan,Lim, Si-Kyu,Sohng, Jae Kyung,Yoon, Yeo Joon
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p. 1091 - 1098
(2013/07/26)
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- Efficient removal of pipecolinate from rapamycin and FK506 by reaction with n-Bu4N+CN-
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The reaction of rapamycin (1) and FK506 (11) with n-Bu4N+CN- / aq. THF results in an efficient excision of their pipecolinate subunits, leading in good yields to compounds 3 and 12, respectively. Two sequential ring cleava
- Luengo, Juan I.,Rozamus, Leonard W.,Holt, Dennis A.
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p. 4599 - 4602
(2007/10/02)
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- Synthesis of Derivatives of FK 506 and FR 900520: Modifications at the Binding Domain
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The synthesis of 9-deoxo-FK 506 (13a), 9-deoxo-FR 900520 (13b), 9-deoxo-10(R)-deoxy-FR900520 (14) and its 10(S) isomer 15 is described.Radical deoxygenation/elimination of the 9-dihydro-9,10-thiocarbonates 5a,5b,6a and 6b gave the 9,10 unsaturated compoun
- Emmer, Gerhard,Weber-Roth, Sabine
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p. 5861 - 5874
(2007/10/02)
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