- 2. 2' - dihydroxy - 4 - methoxy benzophenone preparation method
-
A preparation method of 2,2'-dihydroxy-4-methoxybenzophenone comprises the following steps: synthesizing 2,2'4-trihydroxybenzophenone from salicylic acid and resorcinol, and carrying out a methylation reaction on 2,2'4-trihydroxybenzophenone and dimethyl sulfate to prepare 2,2'-dihydroxy-4-methoxybenzophenone. The method has the advantages of high purification efficiency, good separation effect of byproducts, high product purity reaching 99.5%, and realization of industrial production requirements of the above product.
- -
-
Paragraph 0028; 0029; 0032; 0033; 0036; 0037; 0040-0045
(2017/08/26)
-
- Rh-catalyzed direct synthesis of 2,2′-dihydroxybenzophenones and xanthones
-
An efficient rhodium-catalyzed direct synthesis of 2,2′-dihydroxybenzophenones and xanthones was developed from functionalized salicylaldehydes. This approach provides an easy access to various functionalized 2,2′-dihydroxybenzophenone and xanthone core s
- Rao, Maddali L. N.,Ramakrishna, Boddu S.
-
p. 75505 - 75511
(2016/08/24)
-
- A 2, 2 the [...] -dihydroxy-4-methoxy benzophenone synthetic method
-
The invention provides a synthetic method of 2,2'-dyhydroxyl-4-methoxyl diphenyl ketone. The method comprises the following steps: (1) reacting m-benzene dimethylether with o-methoxybenzoyl chloride for 1-10 hours at the temperature of 0-80 DEG C under the irradiation of light having specific wavelength to obtain an intermediate product 2,2',4-triethoxy diphenyl ketone; (2) carrying out a selective demethylation reaction on the intermediate product 2,2',4-triethoxy diphenyl ketone obtained in the step (1) and a demethylating reagent for 5-16 hours at a reaction temperature of 40-120 DEG C and then performing water washing, liquid separation and recrystallization after the reaction ends to obtain 2,2'-dyhydroxyl-4-methoxyl diphenyl ketone (II). The method is low in reaction energy consumption, high in raw material recovery rate, simple in aftertreatment and small in environment pollution, so the method satisfies the development of environmental-friendly chemistry.
- -
-
Paragraph 0028; 0029; 0031
(2017/01/12)
-
- Cosmetic compositions
-
Suggested is a cosmetic compositions comprising (a) a crosspolymer obtained from copolymerisation of at least two different polyols and at least one dicarboxylic acid and (b) at least one fragrance.
- -
-
-
- A composition for lightening skin and hair
-
Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and/or (b2) at least one sun protection factor; and/or (b3) at least one anti-oxidants; and/or (b4) at least one anti-inflammatory agent; and/or (b5) at least one desquamating agent.
- -
-
-
- Pd-catalyzed sp2 C-H hydroxylation with TFA/TFAA via weak coordinations
-
An efficient sp2 C-H hydroxylation has been developed for the synthesis of a wide range of functionalized phenols with aryl ketones, benzoates, benzamides, acetanilides and sulfonamides through palladium(II) catalysis. A trifluoroacetic acid (TFA)/trifluoroacetic anhydride (TFAA) co-solvent system serves as the oxygen source and is the critical factor for weak coordination promoted C-H activation. Georg Thieme Verlag Stuttgart New York.
- Rao, Yu
-
p. 2472 - 2476
(2013/12/04)
-
- Broadening the catalyst and reaction scope of regio- and chemoselective C-H oxygenation: A convenient and scalable approach to 2-acylphenols by intriguing Rh(ii) and Ru(ii) catalysis
-
A unique Rh(ii) and Ru(ii) catalyzed C-H oxygenation of aryl ketones and other arenes has been developed for the facile synthesis of diverse functionalized phenols. The reaction demonstrates excellent reactivity, regio- and chemoselectivity, good functional group compatibility and high yields. The practicality of this method has been proved by gram-scale synthesis of a few different 2-acylphenols. Its utility has been well exemplified in further applications in heterocycle synthesis and direct modifications of drug Fenofibrate.
- Shan, Gang,Han, Xuesong,Lin, Yun,Yu, Shanyou,Rao, Yu
-
supporting information
p. 2318 - 2322
(2013/04/10)
-
- Pd-catalyzed C-H oxygenation with TFA/TFAA: Expedient access to oxygen-containing heterocycles and late-stage drug modification
-
Functionalized phenols are valuable industrial chemicals related to pharmaceuticals, agrochemicals, and polymers. Therefore, the direct catalytic hydroxylation of arenes to produce phenols has attracted much attention. Although tremendous progress has been made in this field, there are still difficult substrates which remain unmet challenges for direct hydroxylation in terms of regio- and chemoselectivity, as well as the practicality of current methods (Scheme 1). For example, 2-hydroxy aromatic ketones are useful synthetic intermediates for the preparation of various oxygen-containing heterocycles such as benzofuranone, chromanone, benzoxazole, and dibenzooxazepine; they also serve as key building blocks for drugs such as celiprolol, acebutolol, and propafenone. Traditional strategies for accessing 2-hydroxy aromatic ketones have mainly involved the oxidation of benzylic alcohols, the hydrolysis of aromatic halides, Fries rearrangement of esters or the demethylation of methyl phenyl ether. These methods generally suffer from one limitation or another, such as tedious reaction procedures, harsh reaction conditions, low yields, or the formation of side products. Hence, direct transformation of readily available aromatic ketones into valuable 2-hydroxylated products by transition metal-catalyzed C-H functionalization is arguably a highly efficient and atom-economic method to access these compounds. Moreover, developing a more general strategy for the regio- and chemoselective C-H oxygenation of a variety of challenging arenes would be especially desirable for phenol synthesis (Scheme 1).
- Shan, Gang,Yang, Xinglin,Ma, Linlin,Rao, Yu
-
supporting information
p. 13070 - 13074
(2013/02/26)
-
- Synthesis of ortho-acylphenols through the palladium-catalyzed ketone-directed hydroxylation of arenes
-
ortho-Acylphenols are an important structural motif found in a diversity of bioactive molecules ranging from natural products to drugs (Figure 1). Moreover, they also serve as versatile building blocks for the synthesis of various pharmaceuticals, such as warfarin, as well as agrichemicals, flavors, and fragrances. Classic approaches to the synthesis of o-acylphenols generally involve a two-step process: acylation of phenols followed by Fries rearrangement of the resulting phenyl esters (Scheme 1a). On the other hand, direct C-acylation of phenols has also been known under more forcing conditions. Although effective, these approaches are often complicated by the formation of undesired p-substituted products when bulky acyl groups need to be introduced, as well as the limited variety of ketones that can be generated.
- Mo, Fanyang,Trzepkowski, Louis J.,Dong, Guangbin
-
supporting information
p. 13075 - 13079
(2013/02/25)
-
- Method of purifying arylphenones
-
Hydroxy and alkyloxy benzophenones, also known as arylphenones, are efficiently and economically purified by contacting them with inorganic phosphorous compounds in the presence of a non-polar solvent. Best results are obtained when the arylphenone is then treated with an activated carbon and/or activated clay.
- -
-
-
- Phosphites and their production and use
-
Phosphites represented by the general formula (I): STR1 wherein R1, R2, R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, an alkylcycloalkyl group having 6 to 12 carbon atoms, an aralkyl group having 7 to 12 carbon atoms or a phenyl group; R3 and R6 independently represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; X1 is a dihydric alcohol residue, wherein HO--X1 --OH defines the corresponding dihydric alcohol from which residue X1, is obtained; and X2 is a direct bond or an alkylene group having 1 to 8 carbon atoms; and the phosphites are useful as stabilizers for organic materials.
- -
-
-
- Piperidine compound, a process for producing the same and a stabilizer using the same
-
2-Methyl-3-(2,2,6,6-tetramethyl-4-piperidylamino)-N-(2,2,6,6-tetramethyl-4-piperidyl)-propionamide represented by the following formula, a process for producing the same and a stabilized organic material composition containing the same wherein the piperidine compound imparts excellent properties, such as light stability or thermal stability to the organic materials. STR1
- -
-
-
- Transparent cosmetic composition that reflects infrared radiation and its use for protecting the human epidermis against infrared radiation
-
Transparent cosmetic composition that reflects infrared radiation and its use for protecting the human epidermis against infrared radiation. The invention relates to a transparent cosmetic composition comprising, by way of an agent that reflects infrared radiation for protecting the human epidermis, a substance which is dispersible in the cosmetic medium used, possessing a reflectance (R) of infrared radiation equal to at least 45%, and of which a 2% strength dispersion in vaseline possesses an optical transmission in the visible of at least 85%, chosen from a diatom of particle size less than 100 microns, hollow glass microspheres of size less than 100 microns, a bismuth oxychloride of particle size less than 75 microns and zirconium powder covered ceramic microparticles of particle size less than 8 microns. This cosmetic composition can also contain 0.5 to 20% by weight of UV-A, UV-B or broad-band screening agents.
- -
-
-
- Light-stable screening cosmetic composition containing bixin combined with a lipid-soluble UV filter and its use for protecting the human epidermis against ultra-violet radiation
-
The invention relates to a light-stable cosmetic composition for protecting the human epidermis against UV radiation, containing at least 0.0025% by weight of bixin combined with at least 1% by weight of one or more lipid-soluble agents screening UV radiation, chosen from 3-benzylidene-dl-camphor, its derivatives and benzophenone derivatives, in a cosmetically acceptable vehicle comprising at least one fatty phase. The bixin takes the form of an oily extract of annatto containing at least 0.1% by weight of bixin.
- -
-
-
- Carbonates of acetylenic alcohols
-
Polymerizable carbonate compounds of the formula: wherein A is an aromatic polycycle, R1 and R2 are independently hydrogen atom or alkyl, and n is 1, 2 or 3, are disclosed. They are useful as a component of nonemanating, self-curing and heat resistant resin compositions.
- -
-
-
- A Study of Grignard Reaction on 3,4-Diarylcoumarins: Part II - Effect of Substituents on Chromene Formation in Grignard Reaction of 4-(2-Hydroxy-phenyl)-3-phenylcoumarin
-
Condensation of 2,2'-dihydroxy-4-methoxybenzophenone (1) with phenylacetic acid gives an inseparable mixture of 4-(2-acetoxyphenyl)-7-methoxy-3-phenylcoumarin (2) and 4-(2-acetoxy-4-methoxyphenyl)-3-phenylcoumarin (3).This isomeric mixture on Grignard reaction with MeMgI leads to a mixture of Z- and E-4-(2-hydroxy-4-methoxyphenyl)-4-(2'-hydroxyphenyl)-2-methyl-3-phenylbut-3-en-2-ols (4 and 5), which on acid treatment undergo cyclisation to 4-(2-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenylchromene (6) as the sole product.However, a mixture of 7-methoxy-3-phenyl-4-(2,4-dipropyloxyphenyl)coumarin (13) and 3-phenyl-7-propyloxy-4-(2-propyloxy-4-methoxyphenyl)coumarin (14), obtained from 2,2',4'-trihydroxy-4-methoxybenzophenone (12) and phenylacetic acid, under similar treatment with MeMgI produces a 60:40 mixture of 7-hydroxy-4-(2-hydroxy-4-methoxyphenyl)-2,2-dimethyl-3-phenylchromene (15) and 4-(2,4-dihydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenylchromene (16). 2,2'-Dihydroxy-5-methylbenzophenone (17), when subjected to a similar reaction sequence, produces a mixture of 4-(2-acetoxyphenyl)-6-methyl-3-phenylcoumarin (18) and 4-(2-acetoxy-5-methylphenyl)-3-phenylcoumarin (19), that gives rise to a 80:20 mixture of 4-(2-hydroxyphenyl)-2,2,6-trimethyl-3-phenylchromene (20) and 4-(2-hydroxy-5-methylphenyl)-2,2-dimethyl-3-phenylchromene (21).The role of substituents on the formation of isomeric mixtures of chromenes has been discussed.
- Sharma, Indra,Salman, M.,Koley, P. L.,Ray, Suprabhat
-
p. 567 - 570
(2007/10/02)
-
- High molecular weight piperidine derivatives as UV stabilizers
-
Substituted high molecular weight hindered spiropiperidine compounds and polymer compositions stabilized by these compounds. The spiropiperidine compounds are prepared by reacting hindered 4-piperidinone hydrochloride with an activated benzene, such as resorcinol, in an acid medium.
- -
-
-