- Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks
-
An approach to synthesis of 2-, 4-, and 5-bromooxazoles is described. The method was optimized, and its scope was extended to all three isomeric parents, as well as various alkyl- and aryl-substituted bromooxazoles. It was found that direct regiocontrolled lithiation followed by reaction with electrophilic bromine source was common for all substrates and led exclusively to the target substituted 2-, 4- and 5-bromooxazoles on multigram scale. The utility of the multipurpose building blocks obtained in this work was demonstrated in the Suzuki–Miyaura cross-coupling reaction under parallel synthesis conditions.
- Solomin, Vitalii V.,Radchenko, Dmytro S.,Slobodyanyuk, Evgeniy Y.,Geraschenko, Oleksandr V.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.
-
p. 2884 - 2898
(2019/03/07)
-
- SPECTROMETRIE DE MASSE DE TRIAZOLIDES ET DE LEURS PRODUITS DE TRANSFORMATION PAR PYROLYSE-ECLAIR SOUS VIDE
-
Besides the formation of acylium ions, the molecular ions of 1-acyl-1,2,4-triazoles substituted (R) at position 3 lose competitively ketene and carbon monoxide after electron impact ionization, but the ketene loss dominates largely if R is a strong electr
- Maquestiau, Andre,Abdelouahab, Fouad Bachir Ben,Flammang, Robert
-
-
