- Synthesis of substituted terpyridine ligands for use in protein purification
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A number of 4,4″-disubstituted terpyridines bearing a 4′-thioethanamine linker, and regioisomers thereof, have been synthesised from 4-substituted picolinates. The substituted terpyridines were immobilised onto epoxy-activated Sepharose FF gel, creating functionalised solid supports for the fractionation of proteins - including antibodies - by mixed mode affinity chromatography. The metal chelating properties of the immobilised ligand render the stationary phase also amenable for use in immobilised metal-ion affinity chromatography (IMAC), and have been demonstrated with the purification of suitably tagged green fluorescent protein (GFP).
- Lin, Chih-Pei,Florio, Pas,Campi, Eva M.,Zhang, Chunfang,Fredericks, Dale P.,Saito, Kei,Jackson, W. Roy,Hearn, Milton T.W.
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- Highly cytotoxic copper(II) terpyridine complexes as anticancer drug candidates
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Cancer is one of the deadliest diseases worldwide. Chemotherapy remains one of the frequently applied treatment modalities in the clinics. However, as the currently applied agents are associated with severe side effects, scientists are searching for novel chemotherapeutic drugs. Within the last decades, Cu(II) polypyridine complexes have received increasing attention as potential anticancer drug candidates. Herein, the biological activity of terminally functionalised mono- and bis-coordinated Cu(II)-2,2′:6′,2″-terpyridine complexes have been investigated. The bis-coordinated compounds were found to have a cytotoxic effect in the nanomolar range in human adenocarcinomic alveolar basal epithelial cells. Promisingly, the complexes were equally active in the corresponding cisplatin resistant cell line, indicating that they could potentially be useful for the treatment of drug resistant tumours.
- Karges, Johannes,Xiong, Kai,Blacque, Olivier,Chao, Hui,Gasser, Gilles
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- Gelation properties of terpyridine gluconic acid derivatives and their reversible stimuli-responsive white light emitting solution
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Two gluconic acid derivatives C3 and C6 bearing a terpyridyl moiety were designed and synthesized. Thanks to the hydrophilic interaction from glucosyl moiety, C3 and C6 can dissolve in polar solvents and gel aromatic solvents with a critical gel concentration of weight 1.5%. The solution consisting of organic ligand C3 as sensitizer and Ln(III) ions as emitters can realize white light emission with thermo- and chemical stimuli-response properties in luminescence spectra. Further, the self-assemblies of C3 and C6 were examined by the combination of the theoretical calculations via hybrid density functional theory (DFT) with 1H nuclear magnetic resonance (1HNMR) and powder X-ray diffraction (PXRD) analysis. The study actually provides a reliable method for the formation of potential functional smart materials.
- Zhang, Yuzhe,Yang, Hewei,Guan, Shuo,Liu, Zihui,Guo, Longyuan,Xie, Jianwei,Zhang, Jiabin,Zhang, Nuonuo,Song, Jian,Zhang, Bao,Feng, Yaqing
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- Healable terpyridine-based supramolecular gels and the luminescent properties of the rare earth metal complex
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Based on gluconic acid acetal and terpyridyl groups, we have prepared two new supramolecular gelators C3S and C6S with the critical gelation concentrations of 0.1% in aryl halides and the ability of gelling in DMF/DMSO + H2O at room temperature. The excellent self-healing properties of the gels were studied using rheological experiments. Based on the 1H NMR, IR spectrum and PXRD, the self-assembly pattern of C6S was proposed through theoretical calculation. After coordinating with Ln(III) metal ions, the multicolor luminescent metallogel C6S-Eu/Tb was investigated. The luminescence properties of the gels were characterized by fluorescence spectroscopy and fluorescence lifetime measurements, confirming the energy transfer between the organic compounds and Ln(III) metal ions.
- Yang, Hewei,Wang, An,Zhang, Limin,Zhou, Xinyu,Yang, Guang,Li, Yanjie,Zhang, Yuzhe,Zhang, Bao,Song, Jian,Feng, Yaqing
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p. 15173 - 15179
(2017/12/15)
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- Efficient synthetic approaches to access ruthenium(II) complexes with 2-(Trimethylsilyl)ethyl- or acetyl-protected terpyridine-thiols
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A series of thiol-functionalized terpyridines (tpy) with protective groups, such as acetyl (Ac), 2-(trimethylsilyl)ethyl (TMSE), and tert-butyl (tBu), and the corresponding ruthenium(II) complexes were synthesized in high yields. The TMSE-protected thiol-
- Wen, Hui-Min,Zhang, Dao-Bin,Zhang, Li-Yi,Shi, Lin-Xi,Chen, Zhong-Ning
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scheme or table
p. 1784 - 1791
(2011/06/25)
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- Use of metal complex compounds as catalysts for oxidation using molecular oxygen or air
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Use, as a catalyst for oxidation reactions using molecular oxygen and/or air, of at least one metal complex compound of formula (1) wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, n and m are each independently of the other an integer having a value of from 1 to 8, p is an integer having a value of from 0 to 32, z is the charge of the metal complex, Y is a counter-ion, q=z/(charge of Y), and L is a ligand of formula (2) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are each independently of the others hydrogen; unsubstituted or substituted C1-C18alkyl or aryl; cyano; halogen; nitro; —COOR12 or —SO3R12 wherein R12 is in each case hydrogen, a cation or unsubstituted or substituted C1-C18alkyl or aryl; —SR13, —SO2R13 or —OR13 wherein R13 is in each case hydrogen or unsubstituted or substituted C1-C18alkyl or aryl; —NR14R15; —(C1-C6alkylene)-NR14R15; —N(+)R14R15R16; —(C1-C6alkylene)-N(+)R14R15R16; —N(R13)—(C1-C6alkylene)-NR14R15; —N[(C1-C6alkylene)-NR14R15]2; —N(R13)—(C1-C6alkylene)-N(+)R14R15R16; —N[(C1-C6alkylene)-N(+)R14R15R16]2; —N(R13)—N—R14R15 or —N(R13)N″R14R15R16, wherein R13 is as defined above and R14, R15 and R16 are each independently of the other(s) hydrogen or unsubstituted or substituted C1-C18alkyl or aryl, or R14 and R15, together with the nitrogen atom linking them, form an unsubstituted or substituted 5-, 6- or 7-membered ring which may contain further hetero atoms. [in-line-formulae][LnMemXp]zYq??(1) [/in-line-formulae]
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Page/Page column 15
(2010/02/15)
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- Synthesis and Co-ordination Behaviour of 6',6''-Bis(2-pyridyl)-2,2':4,4'':2'',2'''-quaterpyridine; 'Back-to-back' 2,2':6',2''-Terpyridine
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The oligopyridine 6',6''-bis(2-pyridyl)2,2':4,4'':2'',2'''-quaterpyridine (L) has been prepared.It may be regarded as a 'back-to-back' analogue of the well known 2,2':6',2''-terpyridine (terpy).Complexes with ruthenium(II) and palladium(II) have been characterised.The diruthenium(II) complex cation 4+ has been shown to exhibit no Ru-Ru interactions, and behaves as two non-interacting Ru(terpy)2 units.
- Constable, Edwin C.,Ward, Michael D.
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p. 1405 - 1409
(2007/10/02)
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