- A substituted including monofluoro-benzene [...] preparation method of the compound (by machine translation)
-
The invention discloses a including monofluoro-benzene substituted [...] compound N - ((3 - (2 - fluoro - 5 - methoxyphenyl) - 1, 2, 4 - oxadiazole - 5 - yl) methyl) aminoethane preparation method, in order to 4 - fluoro anisole as the starting material,
- -
-
Paragraph 0029; 0030
(2018/03/24)
-
- A preparation method of the compound [...] benzene substitution (by machine translation)
-
The invention discloses a benzene substitution [...] compound N - ((3 - (2 - fluoro - 5 - methoxyphenyl) - 1, 2, 4 - oxadiazole - 5 - yl) methyl) aminoethane preparation method, in order to 4 - fluoro anisole as the starting material, through the aldehyde
- -
-
Paragraph 0029; 0030
(2018/03/26)
-
- Synthesis method of fluorobenzene substituted oxadiazole compound
-
The invention discloses a synthesis method of a fluorobenzene substituted oxadiazole compound N-((3-(2-fluoro-5-methoxyphenyl)-1,2,4-oxadiazole-5-yl)methyl)ethylamine. A target product 7 is obtained through hydroformylation, oximation, elimination, additi
- -
-
Paragraph 0029-0030
(2018/07/06)
-
- Mild and general palladium-catalyzed synthesis of methyl aryl ethers enabled by the use of a palladacycle precatalyst
-
A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield.
- Cheung, Chi Wai,Buchwald, Stephen L.
-
supporting information
p. 3998 - 4001
(2013/09/02)
-
- Displacement of Halogen of 2-Halogeno-Substituted Benzonitriles with Carbanions. Preparation of (2-Cyanoaryl)arylacetonitriles
-
(2-Cyanoaryl)arylacetonitriles are obtained by displacement of halogen of 2-halobenzonitriles with phenylacetonitrile anions.The method also applies to a number of heteroaromatics with ortho-situated halogen and cyano groups and to heteroarylacetonitrile anions.The anions were generated by using potassium tert-butoxide or potassium carbonate.Calculated electron densities of the electrophilic centers reflect the reactivity in the displacement reaction.The calculations indicate that the potassium ion complexes with the cyano group of the 2-halobenzonitriles in nonpolar solvents, thus promoting competitive addition of the anion to the cyano group.Carbanions derived from acids with pKa ca. 19-23 similarly displaced the halogen of 2-halobenzonitriles.
- Bech Sommer, Michael,Begtrup, Mikael,Boegesoe, Klaus Peter
-
p. 4817 - 4821
(2007/10/02)
-
