- Microbial Production of 3aα-H-4α-(3'-Propionic acid)-5α-hydroxy-7aβ-methylhexahydro-1-indanone-δ-lactone from Soybean Sterol
-
Fermentative production of 3aα-H-4α-(3'-propionic acid)-5α-hydroxy-7aβ-methylhexahydro-1-indanone-δ-lactone (HIL) from soybean sterol was studied in order to use it as an intermediate for chemical synthesis of 19-norsteroids.A mutant of Nocardia corallina converted 20 g/liter of soybean sterol into 2.8 g/liter of HIL with a 25percent yield on a molar basis.The dominant factors improving the productivity were the use of an amino acid mixture as a nitrogen source and the preparation of the sterol suspension by sonication or with surface-active agents.
- Nakamatsu, Tsuyoshi,Beppu, Teruhiko,Arima, Kei
-
p. 1449 - 1454
(2007/10/02)
-
- DEOXYCHOLIC ACID DEGRADATION BY A PSEUDOMONAS SP: PHENOLIC AND NEUTRAL PRODUCTS
-
The microbial degradation of deoxycholic acid by Pseudomonas sp.MR108 was studied, and four products were isolated.Evidence is presented that one is the phenol 3,12β-dihydroxy-9,10-secoandrosta-1,3,5(10)-trien-9,17-dione (11) and that the other three are the neutral compounds 3aαH-4α--5α-hydroxy-7aβ-methyl-hexahydro-1-indanone-δ-lactone (12), 12β-hydroxyandrosta-1,4-dien-3,17-dione (10), and 12α-hydroxyandrosta-1,4-dien-3,17-dione (7).
- Leppik, R. A.
-
p. 1747 - 1751
(2007/10/02)
-
