- PHOSPHORUS LIGANDS AND METHODS OF USE
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In one embodiment, the application discloses ligands, such as a ligand from a dihydrobenzo [1,3] oxaphosphole scaffold, and palladium or other transition metal complexes comprising the ligands and methods for performing cross coupling reactions and asymmetric cross coupling reactions with high selectivity and efficiency, under aqueous micellar catalysis conditions.
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- HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature
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The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures.
- Handa, Sachin,Andersson, Martin P.,Gallou, Fabrice,Reilly, John,Lipshutz, Bruce H.
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supporting information
p. 4914 - 4918
(2016/04/26)
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- NOVEL CHIRAL PHOSPHORUS LIGANDS
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The invention relates to a series of novel chiral phosphorus ligands of formulae (Ia) and (Ib): wherein R, 1 - rR> 4 and X are as defined herein. The invention also relates to chiral metal complexes prepared with these chiral phosphorus ligands. The chira
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Page/Page column 24-25
(2011/06/11)
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- Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation
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"Chemical Equation Presented" A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as α-ary lenam ides, α-(acylamino)acrylic acid derivatives, β-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON)
- Tang, Wenjun,Qu, Bo,Capacci, Andrew G.,Rodriguez, Sonia,Wei, Xudong,Haddad, Nizar,Narayanan, Bikashandarkoil,Ma, Shengli,Grinberg, Nelu,Yee, Nathan K.,Krishnamurthy, Dhileep,Senanayake, Chris H.
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supporting information; experimental part
p. 176 - 179
(2010/03/30)
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