PEPTIDE SYNTHESIS BY A COMBINATION OF SOLID-PHASE AND SOLUTION METHODS I: A NEW VERY ACID-LABILE ANCHOR GROUP FOR THE SOLID PHASE SYNTHESIS OF FULLY PROTECTED FRAGMENTS
The synthesis of a new polymeric support for the preparation of fully protected peptide fragments by the Fmoc/t-butyl method is described.Data for coupling yields and racemization data are given.Cleavage from the resin is performed by very mild acidolysis.
SASRIN(TM) resin is synthesized by a two step sequence involving linking 4-hydroxy-2-methoxybenzaldehyde to Merrifield resin, followed by reduction with sodium borohydride.
Katritzky, Alan R.,Toader, Dorin,Watson, Karen,Kiely, John S.