118745-41-8

A 70% ethanol extract of the roots of Livistona chinensis has been investigated, led to the isolation of 13 compounds, including a new ceramide, (2S,3S,4R,9Z)-2-[(2R)-2-hydroxytricosanoylamino]-9-octadecene-1,3,4-triol (2), a new glycosyl ceramide, 1-O-β-d-glucopyranosyl-(2S,3S,4R,9Z)-2-[(2R)-2- hydroxydocosanoylamino]-9-octadecene-1,3,4-triol (3), three new monoacylglycerols, 1-(34-hydroxytetratriacontanoyl)-sn-glycerol (9), 1-[nonadeca-(9Z,12Z)-dienoyl]-sn-glycerol (10), and 1-[12-hydroxypentatriaconta- (13E,15Z)-dienoyl]-sn-glycerol (11), a new diacylglycerol, 1-(heptadeca-6Z,9Z- dienoyl)-3-(octadeca-6Z,9Z,12Z-trienoyl)-sn-glycerol (12), as well as a new diacylglycerol aminoglycoside, 1-octadecanoyl-2-nonadecanoyl-3-O-(6-amino-6- deoxy)-β-d-glucopyranosyl-sn-glycerol (13). The structures of new compounds were elucidated, based on spectroscopic, zymologic and chemical methods. Among the compounds tested, compounds 3, 4 and 13 showed significantly antiproliferative effects against the human tumor cell lines (K562, HL-60, HepG2, and CNE-1) with the IC50 of 10-65 μM. To our knowledge, this is first report of the occurrence of ceramides and acylglycerols in the genus Livistona.

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Two new cerebrosides, 1-O-(β-d-glucopyranosyloxy)-(2S,3S,4R,8Z)-2-[(2′R)-2′-hydroxytricosanoylamino]-8-nonadecene-3,4-diol (1) and 1-O-(β-d-glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2′R)-2′-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol (2), were isolated from the pollen of Typha angustifolia. Their structures were elucidated by chemical and spectral means. This is the first report on the occurrence of cerebroside in Typha (Typhaceae). Compounds 1 and 2 exhibited effect on the proliferation of cultured vascular smooth muscle cell (VSMCs) induced by fatal bovine serum (FBS).

A new cerebroside, 1-O-β-d-glucopyranosyl-(2S,3S,4R,10E)-2-[(2′R)-2′-hydro xyltricosanoyl-amino]-10-octadecene-1,3,4-triol was isolated from the aerial parts of Gynura divaricata DC. Crown Copyright

The glycosphingolipid (GSL) composition of the starfish Pentaceraster regulus has been studied. The structure of the major component, a new cerebroside named Reguloside A (1) and two minor homologues, Regulosides B (1a) and C (1b), are described. VCH Verlagsgesellschaft mbH, 1997.