The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4′-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside
Novel phosphoramidate ProTides derived from 4′-azidoinosine have been prepared and evaluated in the replicon assay against hepatitis C Virus (HCV). The parent nucleoside analogue is inactive in this assay, while the ProTides are active at low μM levels in
McGuigan, Christopher,Daverio, Felice,Najera, Isabel,Martin, Joseph A.,Klumpp, Klaus,Smith, David B.
scheme or table
p. 3122 - 3124
(2010/02/28)
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