- Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach
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The synthesis of 8-aminoquinolines and 1,10-phenanthrolines with substituents in α of the nitrogen has been performed through an inverse-demanding aza-Diels-Alder (Povarov reaction) in the fluoroalcohols TFE or HFIP. This path involves simple starting materials: 1,2-phenylenediamines, enol ethers and aldehydes.
- De, Kavita,Legros, Julien,Crousse, Benoit,Chandrasekaran, Srinivasan,Bonnet-Delpon, Daniele
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- Nitrogen-containing organic compound, application, and organic electroluminescent device using same
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The invention relates to a nitrogen-containing organic compound, an application thereof and an organic electroluminescent device using the same. The chemical structure of the nitrogen-containing organic compound takes pyridinoquinazoline as the center, wh
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Paragraph 0082-0084
(2020/05/30)
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- Transition-Metal-Free Regioselective C–H Bond Fluorination of 8-Amidoquinolines with Selectfluor
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A simple and efficient transition-metal-free protocol for the regioselective C–H bond fluorination of 8-aminoquinoline scaffolds with Selectfluor was developed. The reaction has a broad substrate scope and provides facile access to the corresponding C-5 f
- Chen, Hao,Li, Pinhua,Wang, Min,Wang, Lei
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p. 2091 - 2097
(2018/05/31)
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- QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
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Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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Paragraph 0211; 0212
(2016/08/17)
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- Synthesis and structures of tridentate ketoiminate zinc complexes that act as l-lactide ring-opening polymerization catalysts
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A series of NNO tridentate Schiff base ligands were used to prepare zinc amide and zinc phenoxide complexes that were shown to be efficient l-lactide ring-opening polymerization (ROP) catalysts. The complexes were prepared from ketoimines bearing a pendant quinoline donor, zinc bis(trimethylsilyl)amide, and 2,6-di-tert-butylphenol. They were characterized with 1H and 13C NMR, absorbance spectroscopy, microanalysis, and X-ray crystallography. The zinc amide and zinc phenoxide structures showed mononuclear complexes with tridentate coordination by the ketoiminate ligands. ROP of l-lactide with the zinc amides and phenoxide complexes gave isotactic poly-l-lactide with generally low molecular weight distributions. As compared to their amide counterparts, the zinc phenoxide complexes showed superior lactide ROP behavior in terms of percent conversion as a function of time, measured molecular weights closer to the predicted values, and lower polydispersity index values. Increasing size of the substituent at the 2-position on quinoline (H, Me, Ph) improved the synthesis of the complexes but adversely affected the ROP.
- Roberts, Courtney C.,Barnett, Brandon R.,Green, David B.,Fritsch, Joseph M.
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experimental part
p. 4133 - 4141
(2012/07/14)
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