- Iron- or Zinc-Mediated Synthetic Approach to Enantiopure Dihydroquinoxalinones
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A general and efficient synthesis of enantiopure dihydroquinoxalinones has been developed using naturally occurring amino acids as starting materials. The reductive cyclization of N-(o-nitroaryl)amino esters was performed by using iron and zinc metal under mild conditions in a water/ethyl acetate mixture. The corresponding dihydroquinoxalinones were obtained in moderate to high yields and high enantiomeric purity, among which 7 new compounds were unprecedented in the literature.
- Li, Dazhi,Ollevier, Thierry
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supporting information
p. 1273 - 1280
(2019/01/04)
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- Polycyclic Nitrogen Compounds. Part I. Synthesis of New Heterotricyclic Quinoxalinones with Bridgehead Nitrogen Atoms
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New tricyclic quinoxalinone skeletons with a fully-reduced ring 'C' -1,2,3,3a-tetrahydropyrroloquinoxalin-4-one (I-II) and 7,8,9,10-tetrahydropyridoquinoxalin-6-one (III-IV) derivatives were obtained by selective hydrogen transfer reductive cyclisation of N-(2-nitrophenyl)pyrrolidine-2-carboxylic acid esters and N-(2-nitrophenyl)piperidine-2-carboxylic acid esters (VIa,b and VIIIa,b), respectively.
- Adegoke, E. A.,Alo, Babajide I.,Ogunsulire, F. O.
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p. 1169 - 1172
(2007/10/02)
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