- ION SENSOR
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Provided is a compound useful as a polyvalent metal ion sensor for calcium ions or the like which is capable of reversible sensing and of being integrated into a device, and an ion sensor using the compound. A copolymer comprising: a repeating unit (A) ha
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- Salts of Fatty Acids and Methods of Making and Using thereof
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Disclosed are methods of making salts of fatty acids (e.g., marine oils) and to salts prepared by the disclosed methods. Methods of using the disclosed salts are also disclosed.
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- Formulation for spray-drying large porous particles
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Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solu
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- Soap and process for cleaning wash water
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Agents are used as cleaning agents and also as agents to purify the water in water treatment plants. The agents are a mixture of phosphates and fatty acid salts. Precipitation agents are used such as, polyvalent metals. The pH is adjusted. Flocking agents can be used to increase the rate of separation. The purified water is removed after precipitation.
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- Processes for preparation of 2-alkyl-2adamantyl esters
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A magnesium halide salt of a 2-alkyl-2-adamantanol is reacted with a carboxylic acid halide such as acrylic chloride or the like in the presence of a tertiary amine to produce a 2-alkyl-2-adamantyl ester (the first invention). A 2-alkyl-2-adamantanol is reacted with a carboxylic acid such as acrylic acid or the like in the presence of an acid catalyst such as concentrated sulfuric acid or the like and a drying agent composed of an acidic or neutral inorganic compound (e.g. magnesium sulfate) which is a solid at ordinary temperature in a dried state or of a water-absorbing high-molecular compound, to produce a 2-alkyl-2-admantyl ester (the second invention). The above ester is important as a raw material for a resist for semiconductor production.
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- Metal oxide doped cerium oxides, method for the preparation thereof, resin composition and cosmetic composition therewith
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The present invention relates to the metal oxide doped cerium oxide which has an excellent ultraviolet ray shielding effect and a transparency and whose catalytic activity is reduced. More in detail, relates to the metal oxide doped cerium oxide composed
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- Process for electrophilic aromatic substitution
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Processes for the electrophilic substitution of aromatic compounds, such as alkylation, with a desired substituent are disclosed. The processes include contacting the aromatic compound, a precursor of the desired substituent and an aqueous reagent containing zinc halide at elevated temperatures such as above 50° C.
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- Process for the sulfonation of an aromatic compound
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A subject-matter of the present invention is a process for the sulfonation of an activated or deactivated aromatic compound. The invention applies to the preparation of aromatic sulfones. The process for the sulfonation of an aromatic compound according t
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- Encapsulation of oleophilic substances and compositions produced thereby
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Multiple micro-encapsulations of a high concentration oleophilic substance using heat to set the primary particle renders the composition suitable for the production of free-flowing powders or beadlets. Microencapsulation involves forming an emulsion out
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- Amylase inhibitors
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An amylase inhibitor consisting of a protein constructed of 244 amino acid residues having two subunits each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis, and having a high inhib
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- Cephalosporin antibiotics and processes for preparation thereof
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The present invention relates to a cephalosporin compound represented by the following general formula (I), its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, which is useful as an a
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- Contact lens cleaning composition containing polyalklene oxide modified siloxanes
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Compositions and methods are provided for cleaning and wetting of contact lenses, especially rigid, gas-permeable contact lenses. The compositions comprise low molecular weight polyalkylene oxide modified siloxanes, which are particularly effective in removing lipids from the surface of contact lenses.
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- Odontotherapeutical materials
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An odontotherapeutical material is based on two liquids A and B containing materials capable of forming difficult-to-dissolve precipitations immediately by mixing. The liquids A and B are successively applied on the affected region.
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- Benzodiazepines, process and intermediates for the preparation thereof and their application in therapy
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Benzodiazepines of formula STR1 in which R1 is H of halogen, R2 is H or halogen, Ar is indolyl, phenyl, naphthyl, indolyl monosubstituted with a halogen or with a methoxy or phenyl mono-, di- or trisubstituted with a halogen or with
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- SULFONAMIDO DERIVATIVES INHIBITNG THE ALDOSE REDUCTASE ENZYME SYSTEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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The xanthosulfonamido and benzensulfonamido derivatives corresponding to the formula: wherein x represents hydrogen, alkyl, alkoxy or halogen, Y represents an alkyl, alkoxy or halogen and Z represents the group or Y and Z taken together form the group: wh
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- Sulfonamido derivatives inhibiting the aldose reductase enzyme system and pharmaceutical compositions containing them
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The xantosulfonamido and benzensulfonamido derivatives corresponding to the formula: wherein X represents an alkyl-alkoxy halogen, Y represents an alkyl-alkoxy-halogen and Z represents the group or Y and Z taken together form the group: wherein R1/s
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- N-substituted 2,4-dialkoxy benzenesulfonamides and pharmaceutical compositions
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The invention relates to new N-substituted benzenesulfonamides, the process for their preparation and their use. The compounds according to the invention correspond to the general formula (I): STR1 in which: n and m have values from 0 to 4; R3 and R4 represent in particular a lower alkyl radical; R1 and R2 represent in particular hydrogen atoms, linear or branched alkyl groups having from 1 to 4 carbon atoms; R5 represents particularly a hydrogen atom, a halogen, the NO2, NH2, or CF3 group; R6 and R7 represent in particular a hydrogen atom, an alkyl radical of 1 to 6 carbon atoms. The invention is useful in the preparation of tranquilizing or anxiolytic medicines.
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- Derivatives of pyrido-benzothiazine with high anti-microbial activity
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Pyrido-benzothiazine compounds having anti-microbial activity are prepared by (a) reacting 3-chloro-4-fluoroaniline with potassium thiocyanate and bromine to produce 2-amino-6-fluoro-7-chlorobenzothiazole, (b) reacting 2-amino-6-fluoro-7-chlorobenzothiazole with sodium hydroxide to produce the disulfide of 2-amino-5-fluoro 6-chlorothiophenol, (c) reacting the disulfide with sodium monochloroacetate to produce 7-fluoro-8-chloro-2H-1,4-benzothiazin-3(4H)-one, (d) reducing 7-fluoro-8-chloro-2H-1,4-benzothiazin-3(4H)-one to produce 7-fluoro-8-chloro-3,4-dihydro-2H-1,4-benzothiazone, (e) reacting 7-fluoro-8-chloro-3,4-dihydro-2-H-1,4-benzothiazone with ethyl ethoxymethylenemalonate and cyclyzing the intermediate formed with polyphosphoric acid to produce ethyl 9-fluoro-10-chloro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3 de] [1,4]-benzothiazine-6-carboxylate and (f) hydrolyizing the ethyl carboxylate to produce the corresponding carboxylic acid.
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- Fluid for traction drive
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The fluid for traction drive containing: (A) an alkane derivative having at least three cyclohexane rings in a molecule; and (B) an alkane derivative having a main chain of two or three carbon atoms, to which at least two methyl groups are bonded, and having two cyclohexane rings in a molecule each bonded to one of the terminal carbon atoms of the alkane, or a cyclopentane derivative having two cyclohexane rings in a molecule, and which has a kinematic viscosity of at least 3 centistokes at 100° C. The fluid has a high traction coefficient with stability over a wide range of temperature.
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- Biologic and method of preparing same
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A method is described for the production of large quantities of biologic which serves as an immunomodulator and also to decrease the concentration of serum cholesterol and triglycerides. In practice, an animal such as a goat is injected with a virus (pref
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- Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors
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Fluoroalkoxy compounds of the general formula I STR1 wherein R1 represents a 1-3C-alkyl radical which is completely or predominantly substituted by fluorine, or a chlorodifluoromethyl radical, R1' represents hydrogen, halogen, trifluoromethyl, a 1-3C-alkyl radical, or a 1-3C-alkoxy radical which is optionally completely or predominantly substituted by fluorine, R2 represents hydrogen or a 1-3C-alkyl radical, R3 represents hydrogen or a 1-3C-alkyl or 1-3C-alkoxy radical, R4 represents hydrogen or a 1-3C-alkyl radical and n represents the number 0 or 1, and their salts are new compounds with a marked protective effect on the stomach.
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- Substituted 2,4 dialkoxy benzene sulfonyl chlorides
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The invention relates to trisubstituted sulfohalides, the process for their preparation and their use as intermediate products for the manufacture of novel compounds. The trisubstituted sulfohalides according to the invention correspond to the following general formula (I): STR1 in which: X is a halogen atom, particularly bromine or preferably chlorine; R3 and R4 each represent, independently of one another, a lower alkyl radical having from 1 to 4 carbon atoms, A represents hydrogen, halogen, alkoxy radicals having from 1 to 4 carbon atoms, alkylsulfonyl groups having from 1 to 4 carbon atoms, or the group NO2, or CF3. The invention is useful in the manufacture of medicaments.
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- Blood-coagulation-promoting preparation based on human proteins and a method of producing the same
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In a method of producing a blood-coagulation-promoting preparation based on human proteins and having a content of coagulation factors II, VII, IX and X and factor-VIII-inhibitor-bypassing-activity (FEIBA), human plasma is treated with sulphated high-poly
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- Antibacterial agents, and 4-thio azetidinone intermediates
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This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula STR1 wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.
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- Process for producing triallyl isocyanurate
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A process for producing tri(allyl isocyanurate) by reacting an alkali cyanate and an allyl halide in an aprotic polar solvent, which comprises distilling off the solvent after the completion of the reaction, adding water or an aqueous solution of hydrogen
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- 1-Chloro-prop-2-ene-3-sulfonic acid compounds and their manufacture
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The new 1-monochloro- and 1,1-dichloro-prop-2,3-ene-3-sulfonic acids and their metal salts, and a process for their manufacture by reacting chloropropanesulfonic acid compounds with alkali metal carbonates, alkali metal bicarbonates and/or alkaline earth
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- Substituted 2-aminomethylphenyl sulfamates
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Substituted 2-aminomethylphenyl sulfamates and pharmaceutically acceptable acid addition salts wherein the sulfamate group is N-substituted with up to 2 groups and the phenyl nucleus is further substituted by from 2 to 4 nuclear substituents which are use
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- α-Alkyl-phosphonosuccinic acid compounds and sequestering compositions containing them
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Certain novel α-alkyl-phosphonosuccinic acid compounds of the formula STR1 in which R is lower alkyl, or alkenyl or alkynyl, cycloalkyl, or aralkyl are particularly suitable as sequestering agents, e.g., for incorporation into cleansing compositions.
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- Polymerizable ethylenically unsaturated N-substituted 2,2-dihydro carbyl-2,1,3-benzostanna-thiazolines
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Polymerizable ethylenically unsaturated N-substituted 2,2-dihydrocarbyl-2, 1,3-benzostannathiazolines prepared by the reaction at the amino group of a N-(aminobenzenesulfonyl)-2,2-dihydrocarbyl-2,1,3-benzostannathiazoline precursor with an ethylenically u
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- Processes of producing 2,5-disubstituted benzamides
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2,5-Disubstituted benzamides are produced by an efficient, effective and economical method by the utilization of 4-methyl 2-chloro 1-3-2-dioxophosphorinane as a catalyst.
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- 7-Trichloroacetamido-3-desacetoxy-cephalosporanic acid esters
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The invention provides 7-trichloroacetamido-3-desacetoxy-cephalosporanic acid derivatives of the formula: SPC1 Wherein R is a group which protects the carboxylic acid radical, which can be converted into 7-amino-3-desacetoxycephalosporanic acid by replaci
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- Benzophenone ureas and method for utilizing the same
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This invention provides for novel benzophenone ureas, a method for preparing the same, and a method for controlling undesirable broadleaf weeds and grasses therewith, wherein said benzophenone is represented by the generic formula: SPC1 Where A and B each represent hydrogen, methyl, halogen, trifluoromethyl, or methoxy; R1 and R2 are taken singly or in combination and represent hydrogen, lower alkyl, alkoxy, alkoxyalkyl, cycloalkyl, cyclohetero, loweralkylamino, lower alkenyl or lower alkynyl, with the proviso that A is either meta or para to the --HN--CO--NR1 R2 substituent.
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- Monoazo pigments
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Monoazo pigments of the general formula STR1 WHEREIN X is hydrogen or halogen, preferably chlorine or bromine, alkyl, alkoxy, trifluoromethyl, phenyl, phenoxy or cyano, Y represents hydrogen or halogen, preferably chlorine or bromine, alkyl, alkoxy, carbo
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