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| Name |
Bumetanide |
EINECS | 249-004-6 |
| CAS No. | 28395-03-1 | Density | 1.347 g/cm3 |
| PSA | 127.10000 | LogP | 4.89060 |
| Solubility | Soluble in ethanol (10 mg/ml), DMSO (25 mg/ml), acetone, benzene, methanol, propylene glycol, and water (<1 mg/ml). | Melting Point |
230-231 °C |
| Formula | C17H20N2O5S | Boiling Point | 571.2 °C at 760 mmHg |
| Molecular Weight | 364.422 | Flash Point | 299.3 °C |
| Transport Information | N/A | Appearance | crystalline solid |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI);3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid;3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid;Bumex;Burinex;Fontego;Fordiuran;Lixil;Lunetoron;PF1593;Ro 10-6338; |
Bumetanide Chemical Properties
Molecular Structure of Bumetanide (CAS NO.28395-03-1):
.gif)
IUPAC Name: 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Molecular Formula: C17H20N2O5S
Molecular Weight: 364.416100 g/mol
EINECS: 249-004-6
Melting Point: 230-231 °C
Density: 1.347 g/cm3
Flash Point: 299.3 °C
Enthalpy of Vaporization: 90.11 kJ/mol
Boiling Point: 571.2 °C at 760 mmHg
Vapour Pressure: 6.89E-14 mmHg at 25 °C
Water Solubility: 32.22 mg/L at 25 °C
Appearance: Crystalline Solid
Classification Code: Diuretic; Diuretics; Drug / Therapeutic Agent; Membrane Transport Modulators; Natriuretic Agents; Sodium Potassium Chloride Symporter Inhibitors
Bumetanide Uses
Bumetanide (CAS NO.28395-03-1) is used to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective with the brand name Bumex.
Bumetanide Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | > 500ug/kg (0.5mg/kg) | BEHAVIORAL: TETANY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972. |
| dog | LDLo | oral | > 500ug/kg (0.5mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 66, 1972. |
| mammal (species unspecified) | LD50 | intravenous | 6200ug/kg (6.2mg/kg) | Journal of Clinical Pharmacology. Vol. 21, Pg. 543, 1981. | |
| mouse | LD50 | intramuscular | > 25mg/kg (25mg/kg) | Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976. | |
| mouse | LD50 | intraperitoneal | 519mg/kg (519mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
| mouse | LD50 | intravenous | > 200mg/kg (200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
| mouse | LD50 | oral | 4624mg/kg (4624mg/kg) | Drugs in Japan Vol. 6, Pg. 683, 1982. | |
| mouse | LD50 | subcutaneous | 1660mg/kg (1660mg/kg) | Drugs in Japan Vol. 6, Pg. 683, 1982. | |
| rabbit | LD50 | intravenous | 70mg/kg (70mg/kg) | Postgraduate Medical Journal, Supplement. Vol. 51(Suppl, | |
| rabbit | LD50 | oral | 350mg/kg (350mg/kg) | Postgraduate Medical Journal, Supplement. Vol. 51(Suppl, | |
| rat | LD50 | intramuscular | > 5mg/kg (5mg/kg) | Yakkyoku. Pharmacy. Vol. 27, Pg. 1057, 1976. | |
| rat | LD50 | intraperitoneal | 891mg/kg (891mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979. | |
| rat | LD50 | intravenous | > 200mg/kg (200mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
| rat | LD50 | oral | > 6gm/kg (6000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 614, 1976. |
Bumetanide Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of SOx and NOx.
Safety Information of Bumetanide (CAS NO.28395-03-1):
WGK Germany: 3
RTECS: DG4910000
Bumetanide Specification
Bumetanide (CAS NO.28395-03-1), its Synonyms are Benzoicacid, 3-(butylamino)-4-phenoxy-5-sulfamoyl- (8CI) ; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid ; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid ; 3-n-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid ; Bufenox ; Bumex ; Burinex ; Edemex ; Fontego ; Fordiuran ; Lixil ; Lunetoron .
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