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Conditions | Yield |
---|---|
Stage #1: 2,2-dimethyl-3-hydroxypropionaldehyde With sodium hydroxide at 85 - 95℃; for 2h; Stage #2: With ammonium hydroxide; H1044 at 60℃; for 8h; pH=7 - 9; | 91% |
With phosphotungstic acid; dihydrogen peroxide In water at 55℃; for 2h; Temperature; Reagent/catalyst; Time; | 85% |
With sodium hydroxide; oxygen; palladium/alumina at 39.85℃; under 760 Torr; Kinetics; Further Variations:; Temperatures; | |
Multi-step reaction with 2 steps 1: water; aluminium amalgam 2: potassium permanganate View Scheme |
N-[3-acetoxy-2,2-dimethylpropanoyl]-S-methyl-S-2-pyridylsulfoximine
A
3-Hydroxy-2,2-dimethylpropanoic acid
B
imino(methyl)(pyridin-2-yl)-λ6-sulfanone
Conditions | Yield |
---|---|
With hydrogenchloride; water at 50℃; for 3h; | A 88% B 87% |
Methyl 2,2-dimethyl-3-hydroxypropionate
3-Hydroxy-2,2-dimethylpropanoic acid
Conditions | Yield |
---|---|
With water; lithium hydroxide In tetrahydrofuran; methanol at 0 - 20℃; for 1.5h; | 73% |
With lithium hydroxide In tetrahydrofuran; methanol; water at 20℃; for 1.3h; | |
With lithium hydroxide In tetrahydrofuran; methanol; water at 0 - 20℃; |
3-Hydroxy-2,2-dimethylpropanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water for 12h; Inert atmosphere; Schlenk technique; Reflux; | 56% |
Conditions | Yield |
---|---|
Stage #1: formaldehyd; L-valine With ketopantoate hydroxymethyltransferase; nickel dichloride at 20℃; for 24h; pH=7.5; Enzymatic reaction; Stage #2: With dihydrogen peroxide pH=7.5; Stage #3: With catalase from bovine liver In aq. phosphate buffer pH=7; Enzymatic reaction; | 51% |
carbon monoxide
3-hydroxy-2-methyl-1-propene
A
dihydro-4-methyl-2(3H)-furanone
B
3-Hydroxy-2,2-dimethylpropanoic acid
Conditions | Yield |
---|---|
Stage #1: carbon monoxide; 3-hydroxy-2-methyl-1-propene With dicarbonylacetylacetonato rhodium (I); 2-isopropoxy-1-methyl-3-phenyl-2,3-dihydro-1H-benzo[d][1,3]azaphosphole; hydrogen; toluene-4-sulfonic acid In benzene at 45℃; under 20686.5 Torr; for 12h; Stage #2: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene In water; tert-butyl alcohol at 20℃; regioselective reaction; | A n/a B 49% |
2,2-dimethyl-3-hydroxypropionaldehyde
A
3-Hydroxy-2,2-dimethylpropanoic acid
B
2,2-Dimethyl-1,3-propanediol
Conditions | Yield |
---|---|
With potassium carbonate | |
With potassium carbonate |
3-hydroxy-2,2-dimethylpropionitrile
3-Hydroxy-2,2-dimethylpropanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride |
3-acetoxy-2,2-dimethyl-propionitrile
3-Hydroxy-2,2-dimethylpropanoic acid
Conditions | Yield |
---|---|
Verseifung; |
2,2-dimethyl-3-pivaloyloxy-propionic acid
3-Hydroxy-2,2-dimethylpropanoic acid
Conditions | Yield |
---|---|
Hydrolysis; |
Molecular structure of Propanoic acid,3-hydroxy-2,2-dimethyl- (CAS NO.4835-90-9) is:
Product Name: Propanoic acid,3-hydroxy-2,2-dimethyl-
CAS Registry Number: 4835-90-9
IUPAC Name: 3-hydroxy-2,2-Dimethylpropanoic acid
Molecular Weight: 118.1311 [g/mol]
Molecular Formula: C5H10O3
XLogP3-AA: 0
H-Bond Donor: 2
H-Bond Acceptor: 3
EINECS: 203-874-3
Melting Point: -16 °C(lit.)
Refractive index: n20/D 1.5215(lit.)
Surface Tension: 43.1 dyne/cm
Density: 1.144 g/cm3
Flash Point: 114.9 °C
Enthalpy of Vaporization: 55.75 kJ/mol
Boiling Point: 242.8 °C at 760 mmHg
Vapour Pressure: 0.00567 mmHg at 25°C
Safty information about Propanoic acid,3-hydroxy-2,2-dimethyl- (CAS NO.4835-90-9) is:
Hazard Codes: Xi
Risk Statements: 36
R36:Irritating to eyes.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 1
RTECS: KM2975000
F: 3-13-23
Propanoic acid,3-hydroxy-2,2-dimethyl- , its cas register number is 4835-90-9. It also can be called 3-Hydroxypivalic acid ; 2,2-Dimethyl-3-hydroxypropionic acid .