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Name |
2-Thiazolamine,5-(4-pyridinyl)- |
EINECS | N/A |
CAS No. | 40353-55-7 | Density | 1.333 g/cm3 |
PSA | 80.77000 | LogP | 1.71740 |
Solubility | N/A | Melting Point |
N/A |
Formula | C8H7N3S | Boiling Point | 378.931 °C at 760 mmHg |
Molecular Weight | 177.23 | Flash Point | 182.971 °C |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
5-(Pyridin-4-yl)-1,3-thiazol-2-amine;5-(4-Pyridinyl)-2-thiazolamine; |
Article Data | 6 |
Conditions | Yield |
---|---|
With triethylamine In ethanol at 60℃; for 20h; | 86% |
With triethylamine In ethanol at 60℃; for 20h; | 86% |
2,2-dimethyl-N-(5-pyridin-4-yl-thiazol-2-yl)propionamide
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
With hydrogenchloride for 4h; Reflux; | |
With hydrogenchloride In water for 2h; Reflux; | |
With hydrogenchloride In water for 2h; Reflux; |
N-tert-butoxycarbonyl-L-phenylalanine
trifluoroacetic acid
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine; 5-pyridin-4-yl-thiazol-2-ylamine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 50℃; for 6h; Stage #2: trifluoroacetic acid In water; acetonitrile for 0.75h; |
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 50 °C 1.2: HPLC columh / 0.75 h 2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C 3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 70 °C / Inert atmosphere 3.2: HPLC columh / 0.5 h View Scheme |
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 50 °C 1.2: HPLC columh / 0.75 h 2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C View Scheme |
3,4-dichlorophenylisocyanate
5-pyridin-4-yl-thiazol-2-ylamine
1-(3,4-dichlorophenyl)-3-(5-(pyridin-4-yl)thiazol-2-yl)urea
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 90℃; for 1h; |
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 120℃; for 1.5h; Inert atmosphere; Sealed tube; | 70 mg |
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 1.5 h / 120 °C / Inert atmosphere; Sealed tube 2: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxyethane / 24 h / 85 °C / Sealed tube View Scheme |
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / mineral oil / 1 h / 0 °C / Inert atmosphere 2: dimethyl sulfoxide / 1 h / 100 °C 3: hydrogenchloride / water / 0 °C View Scheme |
2,4-dichloro-2-methylpyrimidine
5-pyridin-4-yl-thiazol-2-ylamine
Conditions | Yield |
---|---|
With sodium hydride In mineral oil at 0℃; for 1h; Inert atmosphere; | |
With sodium hydride In 1-methyl-pyrrolidin-2-one; mineral oil at 0℃; for 1h; Inert atmosphere; |
The 2-Thiazolamine,5-(4-pyridinyl)- is an organic compound with the formula C8H7N3S. The systematic name of this chemical is 2-Thiazolamine, 5-(4-pyridinyl)-. With the CAS registry number 40353-55-7, it is also named as 5-(Pyridin-4-yl)-1,3-thiazol-2-amine. Besides, its molecular weight is 177.2263.
The physical properties of 2-Thiazolamine,5-(4-pyridinyl)- are: (1)ACD/LogP: 0.21; (2)ACD/LogD (pH 5.5): 0.205; (3)ACD/LogD (pH 7.4): 0.21; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 30.662; (7)ACD/KOC (pH 7.4): 30.997; (8)#H bond acceptors: 3; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 80.04 Å2; (12)Index of Refraction: 1.67; (13)Molar Refractivity: 49.648 cm3; (14)Molar Volume: 132.925 cm3; (15)Polarizability: 19.682×10-24 cm3; (16)Surface Tension: 65.339 dyne/cm; (17)Density: 1.333 g/cm3; (18)Flash Point: 182.971 °C; (19)Enthalpy of Vaporization: 62.689 kJ/mol; (20)Boiling Point: 378.931 °C at 760 mmHg.
You can still convert the following datas into molecular structure:
(1)SMILES: c1cnccc1c2cnc(s2)N
(2)InChI: InChI=1/C8H7N3S/c9-8-11-5-7(12-8)6-1-3-10-4-2-6/h1-5H,(H2,9,11)
(3)InChIKey: UQQWEGWMBDAOET-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C8H7N3S/c9-8-11-5-7(12-8)6-1-3-10-4-2-6/h1-5H,(H2,9,11)
(5)Std. InChIKey: UQQWEGWMBDAOET-UHFFFAOYSA-N