2-Fluoro-4-methoxyacetophenone supplier

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Cas Database

Name	2-Fluoro-4-methoxyacetophenone	EINECS	N/A
CAS No.	74457-86-6	Density	1.127 g/cm³
PSA	26.30000	LogP	2.03690
Solubility	Insoluble in water	Melting Point	52-54 °C(lit.)
Formula	C₉H₉FO₂	Boiling Point	243 °C at 760 mmHg
Molecular Weight	168.168	Flash Point	97.9 °C
Transport Information	N/A	Appearance	white to light yellow crystal powder
Safety	26-36-37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	1-(2-Fluoro-4-methoxyphenyl)ethanone;1-Acetyl-2-fluoro-4-methoxybenzene;2'-Fluoro-4'-methoxyacetophenone;	Article Data	7

2-Fluoro-4-methoxyacetophenone Synthetic route

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate In dichloromethane at 95℃; for 24h; Sealed tube;	78%
Multi-step reaction with 3 steps 1: sodium acetate / ethanol; water / 2 h / Reflux 2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N-fluorobis(benzenesulfon)imide; potassium nitrate / nitromethane / 24 h / 25 °C 3: hydrogenchloride; water / diethyl ether / 30 h / 20 °C View Scheme

: 456-49-5
1-fluoro-3-methoxybenzene

: 108-24-7
acetic anhydride

A: 51788-80-8
1-(4-fluoro-2-methoxy-phenyl)-ethanone

B: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With lithium perchlorate at 100℃; for 1h;	A 30% B 70%

: 456-49-5
1-fluoro-3-methoxybenzene

: 108-24-7
acetic anhydride

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide at 20 - 35℃;	60.7%
With aluminium trichloride In 1,2-dichloro-ethane for 2h; Ambient temperature;

: 456-49-5
1-fluoro-3-methoxybenzene

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1313430-15-7
C10H12FNO2

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Conditions

Conditions	Yield
With hydrogenchloride; water In diethyl ether at 20℃; for 30h;	26.5 mg

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 676-58-4
methylmagnesium chloride

: 96826-25-4
2-(2-fluoro-4-methoxyphenyl)-2-isopropanol

Conditions

Conditions	Yield
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone; methylmagnesium chloride In tetrahydrofuran; dichloromethane at 0℃; Inert atmosphere; Stage #2: With hydrogenchloride; methanol; water In tetrahydrofuran; dichloromethane at 20℃; Product distribution / selectivity;	99%
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone; methylmagnesium chloride In tetrahydrofuran at 20 - 35℃; for 0.666667h; Inert atmosphere; Stage #2: With water; acetic acid In tetrahydrofuran at 5 - 25℃;	98%
In tetrahydrofuran at -15 - 0℃; for 1h;	95%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 167683-93-4
2-fluoro-4-methoxy-phenol

Conditions

Conditions	Yield
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone With magnesium sulfate; 3-chloro-benzenecarboperoxoic acid In chloroform at 20℃; for 120h; Stage #2: With ammonium hydroxide In methanol; acetonitrile at 20℃; for 3h; Further stages.;	98%
Multi-step reaction with 2 steps 1: mCPBA, MgSO4 / CHCl3 / 12 h / Ambient temperature 2: 94 percent / aq. NH3 / methanol / 1 h / Ambient temperature View Scheme

NH3 (aq): NH3 (aq)

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 167683-93-4
2-fluoro-4-methoxy-phenol

Conditions

Conditions	Yield
In methanol	94%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1434602-18-2
(E)-1-(2-fluoro-4-methoxyphenyl)ethanone oxime

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water pH=5; Reflux;	93%

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 1-(2,6-difluoro-4-methoxyphenyl)ethan-1-one

Conditions

Conditions	Yield
With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate In dichloromethane at 95℃; for 24h; Sealed tube;	93%

2-Fluoro-4-methoxyacetophenone Chemical Properties

The Molecular formula of 2-Fluoro-4-methoxyacetophenone(74457-86-6): C₉H₉FO₂
The Molecular Weight of 2-Fluoro-4-methoxyacetophenone(74457-86-6): 168.16
Molecular Structure :

Melting point: 52-54 °C(lit.)
Boiling Point: 243 °C at 760 mmHg
Flash Point: 97.9 °C
Index of Refraction: 1.487
Molar Refractivity: 42.95 cm³
Molar Volume: 149.1 cm³
Polarizability: 17.02 10-24cm³
Surface Tension: 32.5 dyne/cm
Density: 1.127 g/cm³
Enthalpy of Vaporization: 48 kJ/mol
Vapour Pressure: 0.0329 mmHg at 25°C
Water Solubility: Insoluble
Appearance: white to light yellow crystal powder
IUPAC Name: 1-(2-fluoro-4-methoxyphenyl)ethanone
Synonyms: 2'-FLUORO-4'-METHOXYACETOPHENONE;2-Fluoro-4-methoxyacetophenone 99% (HP&;2-FLUORO-4-METHXOYACETOPHENONE;4-Methoxyphenacyl fluoride;2-Fluoro-4-methoxyacetophenone;1-(2-FLUORO-4-METHOXYPHENYL)ETHANONE;4-ACETYL-3-FLUOROANISOLE;2'-Fluoro-4'-methoxyacetophenone 99%;

2-Fluoro-4-methoxyacetophenone Safety Profile

The Hazard Codes of 2-Fluoro-4-methoxyacetophenone(74457-86-6):

Xi
The Risk Statements information of 2-Fluoro-4-methoxyacetophenone(74457-86-6):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of 2-Fluoro-4-methoxyacetophenone(74457-86-6):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
Hazard Note: Irritant

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2-Fluoro-4-methoxyacetophenone

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