1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound include central nervous system stimulation, vomiting, diarrhea, paresthesia, excitement, giddiness, fatigue, tremors, convulsions, pulmonary edema, hypothermia, headache, loss of appetite muscular weakness, apprehensive mental state, myocardial toxicity, impotence, infertility and coma. It may also cause hyperexcitability, narcosis, central nervous system depression, kidney damage and liver damage. Other symptoms include muscle pains, ataxia, mild delirium and fever. It may also cause skin irritation. Testicular damage can occur. ACUTE/CHRONIC HAZARDS: This compound is moderately toxic by inhalation. It may be absorbed through the respiratory tract, gastrointestinal tract and skin. It may cause irritation of the skin. When heated to decomposition it emits toxic fumes of chlorides.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Skin decontamination. Wash skin with soap and water ... . Eye contamination should be removed by prolonged flushing of the eye with copious amounts of clean water or saline. If irritation persists, specialized medical treatment should be obtained.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback ...

5.2 Specific hazards arising from the chemical

Flash point data for this chemical are not available; however, it is probably combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: P2 filter respirator for harmful particles. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs, strong oxidants, bases and strong acids.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

This chemical may burn but does not easily ignite.CHLOROBENZILATE is hydrolyzed by alkalis and strong acids. Incompatible with lime .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong acids , strong bases, lime.

10.6 Hazardous decomposition products

Emits toxic fumes of /hydrogen chloride/ when heated to decomposition.

11.Toxicological information

Acute toxicity

• Oral: LD50 Rat oral 2784-3880 mg/kg
• Inhalation: no data available
• Dermal: LD50 Rabbit percutaneous >10,000 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

The Carcinogen Assessment Group in EPA's Research and Development Office has evaluated ethyl 4,4-dichlorobenzilate for carcinogenicity. According to their analysis, the weight of evidence for ethyl 4,4-dichlorobenzilate is group B2, which is based on inadequate evidence in humans and sufficient evidence in animals. As a group B2 chemical, ethyl 4,4-dichlorobenzilate is considered a probable human carcinogen.

Reproductive toxicity

No information is available on the reproductive or developmental effects of chlorobenzilate in humans. Injury to the sperm and atrophy of the testes have been observed in rats exposed to chlorobenzilate in their diet. Teratogenic effects were not observed in the offspring of rats exposed to chlorobenzilate in the diet or in rabbits exposed by gavage.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

• Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout, weight 0.8g); Conditions: freshwater, static, 13°C, pH 7.1, hardness 44 mg/L CaCO3; Concentration: 750 ug/L for 24 hr /95.5% purity, technical material
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: The rate at which chlorobenzilate degrades in microbial growth media increases when citrate is incorporated(1). This may be due to a reductive decarboxylation process that the citrate stimulates(1). The half-life of chlorobenzilate in two fine sandy soils was estimated to be 1.5-5 weeks following application of 0.5-1.0 ppm; removal was probably microbial(2). It is decarboxylated to 4,4'-dichlorobenzophenone by a yeast isolated from insecticide treated soil under anaerobic conditions(3,4). In 22 days, 40, 29, and 39% of the (14)C-ring-labeled chlorobenzilate added to sediment-free water samples from 3 fresh water lakes was converted to organic products; no (14)CO2 evolution was detected(5). Addition of sediment to the water samples from the three lakes gave (14)CO2 yields 3.6, 0.0, and 18.3%(5). Chlorobenzilate was metabolized in water from another freshwater lake only when glucose and inorganic nutrients were added and mineralized to (14)CO2 only when sediment was also added to the water(5). Chlorobenzilate, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(6). Half-lives for chlorobenzilate in Lukang silty clay loam and Pincheng clay ranged from 15.1 days at 10°C to 10.8 days at 25°C; and 169.1 days at 10°C to 29.5 days at 25°C, respectively(7).

12.3 Bioaccumulative potential

Measured BCF values for carp (Cyprinus carpio) ranged from 224 to 586 and 256 to 709 at concentrations of 20 ug/L and 2 ug/L, respectively(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is high(SRC).

12.4 Mobility in soil

The Koc of chlorobenzilate is estimated as 1,500(SRC), using a log Kow of 4.74(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that chlorobenzilate is expected to have low mobility in soil. Kd values of 26 and 7.6 have been reported for Lukang and Pincheng soils, respectively, at 20°C; at 40°C, the Kd values reported were 41 and 5.3, respectively(4).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

14.2 UN Proper Shipping Name

14.3 Transport hazard class(es)

14.4 Packing group, if applicable

14.5 Environmental hazards

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

16.Other information

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.