Inhibitory effects of Pemirolast potassium (cas 100299-08-9) and FK506 on degranulation and IL-8 production of eosinophils
-
Add time:07/17/2019 Source:sciencedirect.com
ABSTRACTEosinophils are the key effector cells for allergic inflammation. In order to clarify drugs which can regulate eosinophil function, we investigated the direct effect of Pemirolast potassium (cas 100299-08-9) (anti-allergic drug) and FK506 (immunosupressant) on eosinophil degranulation and cytokine production. Eosinophil degranulation induced by granulocyte-macrophage colony stimulating factor and/or platelet activating factor was inhibited from 10- 4 to 10- 6 mol/L pemirolast (inhibitory effect 66 and 33%, respectively) and 10- 8 mol/L FK506 (inhibitory effect 45%). Pemirolast and FK506 also inhibit interleukin (IL)-8 production by eosinophil. Our data suggest that both pemirolast potassium and FK506 possess direct regulatory effects on human eosinophils and a potential to suppress allergic inflammation.
We also recommend Trading Suppliers and Manufacturers of Pemirolast potassium (cas 100299-08-9). Pls Click Website Link as below: cas 100299-08-9 suppliers
Prev:Chlorovulones, new halogenated marine prostanoids with an antitumor activity from the stolonifer clavularia viridis Quoy and Gaimard
Next:Preventive effects of an antiallergic drug, Pemirolast potassium (cas 100299-08-9), on restenosis after percutaneous transluminal coronary angioplasty) - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Related Products
- Pemirolast potassium
- Potassium (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylate
- Potassium (4-formylphenyl)trifluoroborate
- Potassium (bromomethyl)trifluoroborate
- Potassium (R)-((3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino)(4-hydroxyphenyl)acetate
- Potassium (R)-(4-hydroxyphenyl)((3-methoxy-1-methyl-3-oxoprop-1-enyl)amino)acetate
- Potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate
- Potassium [(cyanomethyl)thio]acetate
- Potassium 1,2,3,6-tetrahydro-5-nitro-2,6-dioxopyrimidine-4-carboxylate
- Potassium 2,2-dimethyl-1,3-dioxolane-4-carboxylate