A comparative study of the effects of cinnarizine, sulpiride and thiethylperazine (cas 1420-55-9) on vestibular nystagmus in rabbits

Add time:09/27/2019    Source:sciencedirect.com

The effects of cinnarizine, sulpiride, thiethylperazine (cas 1420-55-9) and a placebo on vestibular nystagmus in rabbits were investigated. The nystagmus was provoked by means of a torsion swing. A suppressive effect was shown by all drugs and not by the placebo. A fast and strong effect was seen after the administration of sulpiride, however this effect decreased after 1 h. The onset of the effect of cinnarizine was slower but the effect lasted longer. Thiethylperazine had a clear suppressive effect but less strong and shorter than that of the other two drugs.

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