Influence of Aminoglutethimide (cas 125-84-8) and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats
-
Add time:09/29/2019 Source:sciencedirect.com
Antagonists of steroid receptors may interfere with seizure phenomena. The present study deals with effects of Aminoglutethimide (cas 125-84-8) and spironolactone on the action of carbamazepine and diphenylhydantoin in amygdala-kindled rats of both genders. Co-administration of the antimineralocorticoid with carbamazepine at their ineffective doses (50 and 15 mg/kg, respectively) led to significant reduction of the seizure and afterdischarge durations. No anticonvulsant effect was observed when spironolactone was combined with diphenylhydantoin.The concomitant treatment of aminoglutethimide and carbamazepine (both drugs at their subprotective doses of 5 and 15 mg/kg, respectively) resulted in antiseizure activity in respect of all measured parameters, including the afterdischarge threshold, seizure severity, seizure duration and afterdischarge duration. The similar combination of aminoglutethimide with diphenylhydantoin (2.5 mg/kg) significantly shortened the seizure and afterdischarge durations.The antiseizure effect of tested combinations was not sex-dependent and not reversed by hydrocortisone pretreatment. Pharmacokinetic events may be involved only in the interaction between spironolactone and carbamazepine. Among various chemoconvulsants, bicuculline reversed the action of aminoglutethimide on carbamazepine and diphenylhydantoin. The effect of aminoglutethimide on diphenylhydantoin was also abolished by N-methyl-d-aspartic acid and aminophylline. In conclusion, our results suggest that doses of carbamazepine and diphenylhydantoin should be modified in epileptic patients concomitantly treated with aminoglutethimide or spironolactone.
We also recommend Trading Suppliers and Manufacturers of Aminoglutethimide (cas 125-84-8). Pls Click Website Link as below: cas 125-84-8 suppliers
Prev:Aminoglutethimide (cas 125-84-8) included in nanocapsules suspension: comparison of GC–MS and HPLC methods for control
Next:ReviewCaramiphen edisylate: An optimal antidote against organophosphate poisoning) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Aminoglutethimide (cas 125-84-8) included in nanocapsules suspension: comparison of GC–MS and HPLC methods for control09/28/2019
- Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug Aminoglutethimide (cas 125-84-8)10/01/2019
- Proteomic profile of Aminoglutethimide (cas 125-84-8)-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals09/27/2019
- Aminoglutethimide (cas 125-84-8)-imprinted xerogels in bulk and spherical formats, based on a multifunctional organo-alkoxysilane precursor09/26/2019
- Aminoglutethimide (cas 125-84-8)09/25/2019
- Enantioseparation of racemic Aminoglutethimide (cas 125-84-8) using asynchronous simulated moving bed chromatography09/24/2019
- Aminoglutethimide (cas 125-84-8)-induced lysosomal changes in adrenal gland in mice09/10/2019
- Aminoglutethimide (cas 125-84-8)☆09/09/2019
-
Health and Chemical more >
-
Related Products