Decoquinate (cas 18507-89-6) induces tissue cyst formation by the RH strain of Toxoplasma gondii

Add time:09/27/2019    Source:sciencedirect.com

Decoquinate (cas 18507-89-6) is an anticoccidial agent that inhibits respiration in the parasites mitochondrion. We examined human foreskin fibroblast cell cultures infected with the normally tissue cyst-less RH strain of Toxoplasma gondii and treated with decoquinate for evidence of tissue cyst induction and formation. Transmission electron microscopy observations demonstrated tissue cysts in decoquinate-treated cultures on days 3, 4, 5, and 6 after inoculation. Tissue cysts contained a tissue cyst wall that enclosed stages that resembled tachyzoites and stages that were structurally bradyzoites. Similar treatment of human foreskin fibroblast cells infected with tachyzoites of the TS-4 temperature-sensitive mutant of the RH strain did not result in production of tissue cysts.

We also recommend Trading Suppliers and Manufacturers of Decoquinate (cas 18507-89-6). Pls Click Website Link as below: cas 18507-89-6 suppliers

Prev:Efficacy of Decoquinate (cas 18507-89-6) against Neospora caninum tachyzoites in cell cultures
Next:Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors)