Effects of Barnidipine (cas 104757-53-1) hydrochloride, a calcium channel blocker, on renal microcirculation in rats: a pilot study
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Add time:09/05/2019 Source:sciencedirect.com
Barnidipine (cas 104757-53-1) hydrochloride, a dihydropyridine calcium channel blocker, increases both renal blood flow and glomerular filtration while effectively reducing blood pressure. The goal of the present study was to determine the effects of barnidipine on renal microcirculation. We used the rat in vivo split hydronephrotic kidney model to directly observe renal arterioles by light microscopy. When administered into the organ bath (ie, administered from outside of the blood vessels), 10−7 M of barnidipine significantly dilated both afferent and efferent arterioles and increased glomerular blood flow in both normotensive and hypertensive rats. Systolic blood pressure remained unchanged. Intravenous injection of barnidipine 600 μg/kg body weight dilated afferent arterioles and increased glomerular blood flow in normotensive rats. In contrast, the same treatment in hypertensive rats caused significant sustained dilatation of both afferent and afferent arterioles and gradually reduced systolic blood pressure. Future studies are needed to determine the clinical relevance of these effects of barnidipine
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