Anti-phytopathogenic activity and the possible mechanisms of action of Isoquinoline (cas 119-65-3) alkaloid sanguinarine
-
Add time:08/30/2019 Source:sciencedirect.com
Isoquinoline (cas 119-65-3) alkaloids possess broad pharmacological activities. In this study, the antifungal activity of twelve isoquinoline alkaloids, including berberine (1), jatrorrhizine (2), coptisine (3), corydaline (4), tetrahydroberberine (5), chelidonine (6), dihydrosanguinarine (7), chelerythrine (8), sanguinarine (9), palmatine (10), tetrahydropalmatine (11) and columbamine (12) were evaluated against eight plant pathogenic fungi in vitro. All the tested compounds showed varying degrees of inhibition against the eight tested plant fungi. Among them, sanguinarine exhibited high antifungal activity (EC50 ranging from 6.96–59.36 μg/mL). It displayed the best inhibitory activity against Magnaporthe oryzae (EC50 = 6.96 μg/mL), compared with azoxystrobin (EC50 = 12.04 μg/mL), and significantly suppressed spore germination of M. oryzae with the inhibition rate reaching 100% (50 μg/mL). The optical microscopy and scanning electron microscopy observations revealed that after treating M. oryzae mycelia with sanguinarine at 10 μg/mL, the mycelia appeared curved, collapsed and the cell membrane integrity was eventually damaged. Furthermore, the reactive oxygen species production, mitochondrial membrane potential and nuclear morphometry of mycelia had been changed, and the membrane function and cell proliferation of mycelia were destroyed. These results will enrich our insights into action mechanisms of antifungal activity of sanguinarine against M. oryzae.
We also recommend Trading Suppliers and Manufacturers of Isoquinoline (cas 119-65-3). Pls Click Website Link as below: cas 119-65-3 suppliers
Prev:Cholinesterase inhibitory Isoquinoline (cas 119-65-3) alkaloids from Corydalis mucronifera
Next:Bioactive Isoquinoline (cas 119-65-3) alkaloids from Glaucium arabicum) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- First diastereoselective synthesis of perfluoroalkylated cis-spiropyrido[2,1-a]Isoquinoline (cas 119-65-3)-1,5’-pyrimidines09/04/2019
- Highly active and recyclable Pt nanocatalyst for hydrogenation of quinolines and Isoquinoline (cas 119-65-3)s09/03/2019
- Isoquinoline (cas 119-65-3)s from Corydalis tomentella from Tibet, China, possess hepatoprotective activities09/02/2019
- Easy access to synthesize Isoquinoline (cas 119-65-3)s from aryl ketoximes and internal alkynes via Iridium (III)-catalyzed CH/NO bond activation09/01/2019
- Bioactive Isoquinoline (cas 119-65-3) alkaloids from Glaucium arabicum08/31/2019
- Cholinesterase inhibitory Isoquinoline (cas 119-65-3) alkaloids from Corydalis mucronifera08/29/2019
- Highly efficient electrochemiluminescence of quinoline and Isoquinoline (cas 119-65-3) in aqueous solution08/28/2019