Original articleLong-term safety and effectiveness of Pramipexole (cas 104632-26-0) in tetrahydrobiopterin deficiency
-
Add time:08/19/2019 Source:sciencedirect.com
Tetrahydrobiopterin (BH4) deficiencies are inherited neuro-metabolic disorders leading to monoamine neurotransmitters deficiency. An individualized replacement therapy with neurotransmitters precursors is necessary to restore dopaminergic and serotoninergic homeostasis. The correction of dopaminergic tone is complicated, like in Parkinson disease, by l-dopa short half-life and adverse effects. To improve this picture, since 2009 we introduced the non-ergot dopamine agonist Pramipexole (cas 104632-26-0) as an adjunct to l-dopa therapy in the treatment of the most common causes of BH4 deficiency, 6-pyruvoyl tetrahydropterin synthase (PTPS) deficiency and dihydropteridine reductase (DHPR) deficiency. In the short-term period, this approach allowed substantial clinical advantages in affected patients, with amelioration and stabilization of the clinical picture on twice daily treatment administration and no adverse effect.Here we describe the long-term clinical follow-up (83 ± 24 months) of seven patients with BH4 deficiency treated with pramipexole. After a period of good clinical compensation (34 ± 1 months), different impulse control disorders (gambling, compulsive buying, and hypersexuality) were observed in three patients treated with high-dose pramipexole (0.030–0.033 mg/kg/day) beyond adolescence. These psychiatric adverse effects promptly disappeared after curtailing pramipexole dose by 50–60%. Low-dose pramipexole therapy has been safe and effective in the long-term period in all treated patients (59 ± 9 months).High-dose pramipexole therapy in BH4 deficiency can be complicated, like in Parkinson disease, by psychiatric adverse effects. Low-dose pramipexole therapy (∼0.010 mg/kg/day) has been safe and clinically effective on long-term follow-up, representing a helpful therapeutic option in patients with BH4 deficiency.
We also recommend Trading Suppliers and Manufacturers of Pramipexole (cas 104632-26-0). Pls Click Website Link as below: cas 104632-26-0 suppliers
Prev:Pramipexole (cas 104632-26-0) nanocrystals for transdermal permeation: Characterization and its enhancement micro-mechanism
Next:The adrenergic α2 antagonist atipamezole alters the behavioural effects of Pramipexole (cas 104632-26-0) and increases Pramipexole (cas 104632-26-0) concentration in blood plasma) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Original ArticleAdherence and persistence to ropinirole, Pramipexole (cas 104632-26-0), and gabapentin in patients with newly diagnosed restless legs syndrome08/22/2019
- Full paperNeuroprotective effects of Pramipexole (cas 104632-26-0) transdermal patch in the MPTP-induced mouse model of Parkinson's disease08/21/2019
- The adrenergic α2 antagonist atipamezole alters the behavioural effects of Pramipexole (cas 104632-26-0) and increases Pramipexole (cas 104632-26-0) concentration in blood plasma08/20/2019
- Pramipexole (cas 104632-26-0) nanocrystals for transdermal permeation: Characterization and its enhancement micro-mechanism08/18/2019
-
Health and Chemical more >
-
Related Products