Inhibition of Cytochrome P450 by Nomilin (cas 1063-77-0) and Obacunone and Potential Mechanism in Human Liver Microsomes
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Add time:07/25/2019 Source:sciencedirect.com
ObjectiveNomilin (cas 1063-77-0) and obacunone are two important limonoids that are well known for their anticancer effect. Previous studies showed that limonoids had inhibitory effect on cytochrome P450 3A4 (CYP3A4). However these effects are inconclusive with regards to prediction of potential drug interactions.
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