Residue analysis and dietary exposure risk assessment of Tebufenozide (cas 112410-23-8) in stem lettuce (Lactuca sativa L. var. angustana Irish)

Add time:07/22/2019    Source:sciencedirect.com

Tebufenozide (cas 112410-23-8), a newly-developed nonsteroidal ecdysone agonist, is in pre-regulation phase (before approval for use) on stem lettuce in China. Aiming at the safe application of tebufenozide, the dissipation and terminal residue trials on stem lettuce were performed under good agricultural practice (GAP). The dissipation trials shown that tebufenozide was rapidly degraded in stem lettuce, with half-lives of 5.0–8.2 days. Pre-regulation dietary exposure risk assessments were evaluated to recommend maximum residue limits (MRLs) based on risk quotients (RQ) method. Relevant toxicological parameters including ADI (acceptable daily intake) and ARfD (acute reference dose) were applied to assess the potential dietary exposure risk. The results indicated the chronic dietary exposure risk probability (RQc) of tebufenozide ranged from 36.4% to 70.0%. The acute dietary exposure risk probability (RQa) of tebufenozide was 2.88%–8.49% in lettuce stems and 14.0%–20.0% in lettuce leaves, respectively. On the basis of supervised field trial data and dietary exposure risk assessment results, the MRLs of tebufenozide were recommended as 3 mg/kg for lettuce stems and 10 mg/kg for lettuce leaves, respectively. The results demonstrated that the dietary exposure risk of tebufenozide used in stem lettuce under GAP was negligible and would not pose unacceptable health risk to Chinese consumers.

We also recommend Trading Suppliers and Manufacturers of Tebufenozide (cas 112410-23-8). Pls Click Website Link as below: cas 112410-23-8 suppliers

Prev:Cytotoxic effects of Tebufenozide (cas 112410-23-8) in vitro bioassays
Next:Tebufenozide (cas 112410-23-8) induces G1/S cell cycle arrest and apoptosis in human cells)