Voriconazole CAS NO.137234-62-9

product name voriconazole
cas no. 137234-62-9
einecs 200-261-5
m.f. c16h14f3n5o
m.w. 349.31

properties
1)combination with the cyp3a4 substrates, terfenadine, sirolimus, astemizole, cisapride, pimozide or quinidine , can increase blood concentrations of this drug, leading to qt prolongation, and occasionally torsades de pointes ventricular tachycardia.
2)combination with rifampicin, rifabutin, efavirenz, ritonavir (each 400mg, once every 12 hours), carbamazepine and phenobarbital, can significantly lower blood concentrations of voriconazole.
3)combination with ergot alkaloids (ergotamine, dihydroergotamine) plasma concentrations of ergot drugs can cause increased ergot poisoning.

specification
index name spec
appearance white to off-white powder
purity.% 98min
water solubility slightly soluble in water

application
1) it is a triazole antifungal medication, it can cure empirical antifungal therapy.
2) it has become the new standard of care in the treatment of invasive aspergillosis.
3). it can used in the treat of esophageal candidiasis.
4) it has also been used to treat severe fungal corneal infection.
5) an antifungal (systemic). an ergosterol biosynthesis inhibitor.

packing
25kgs/drum

storage
sealed and kept at room temperature.