99839-78-8

Basic information

• Product Name: BenzenepropanaMide, 4-chloro-
• Synonyms: BenzenepropanaMide, 4-chloro-
• CAS NO: 99839-78-8
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.6348
• Mol File: 99839-78-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzenepropanaMide, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzenepropanaMide, 4-chloro-(99839-78-8)
• EPA Substance Registry System: BenzenepropanaMide, 4-chloro-(99839-78-8)

Safety Data

• Hazardous Substances Data: 99839-78-8(Hazardous Substances Data)

Upstream product

• 6318-37-2 5-(4-chlorobenzylidene)rhodanine 
• 102-93-2 3-phenylpropionamide 
• 1073-67-2 4-vinylbenzyl chloride 
• 201230-82-2 carbon monoxide 
• 77287-34-4 formamide 
• 18166-64-8 4-chlorocinnamide 
• 108-90-7 chlorobenzene 
• 18166-64-8 (E)-4-chlorocinnamamide 
• 32327-71-2 3-(4-chlorophenyl)propanenitrile 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 

Downstream Products

• 140-53-4 p-chlorobenzyl cyanide 
• 1226167-01-6 2-(4-chlorophenyl)ethanethioamide 
• 1202651-26-0 2-chloro-4-({3-[2-(4-chlorophenyl)ethyl]-1,2,4-thiadiazol-5-yl}oxy)-5-methylaniline 
• 1202651-28-2 5-[2-(4-chlorophenyl)ethyl]-1,3,4-oxathiazol-2-one 

Relevant articles and documents

Visible-Light Decatungstate/Disulfide Dual Catalysis for the Hydro-Functionalization of Styrenes

We describe an efficient photoredox system, relying on decatungstate/disulfide catalysts, for the hydrofunctionalization of styrenes. In this methodology the use of disulfide as a cocatalyst was shown to be crucial for the reaction efficiency. This photoredox system was employed for the hydro-carbamoylation, -acylation, -alkylation, and -silylation of styrenes, giving access to a large variety of useful building blocks and high-value molecules such as amides and unsymmetrical ketones from simple starting materials.

Primary fatty acid amide preparation method

The present invention provides a primary fatty acid amide preparation method. According to the present invention, under the action of a single auxiliary agent phosphine-containing transition metal catalyst or a combined auxiliary agent comprising a phosphine-free transition metal catalyst and a phosphine-containing ligand, terminally substituted olefin or cyclo-olefin, carbon monoxide and an ammonium salt are subjected to a hydrogen carboamidation reaction so as to prepare the primary fatty acid amide compound in one step; the raw material and the catalyst of the reaction are inexpensive and easy to obtain, and the synthesis process is simple, such that the synthesis cost is substantially reduced; the preparation method has characteristics of mild reaction condition and high yield, and issuitable for industrial production; and the raw material and the catalyst of the reaction are clean, non-toxic and low environment pollution.

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction

The p53 pathway is inactivated in almost all types of cancer by mutations in the p53 encoding gene or overexpression of the p53 negative regulators, Mdm2 and/or Mdmx. Restoration of the p53 function by inhibition of the p53-Mdm2/Mdmx interaction opens up