99184-13-1Relevant articles and documents
Efficient and straightforward synthesis of tetrahydrocarbazoles and 2,3-dimethyl indoles catalyzed by CAN
Varma, P. Prabhakara,Sherigara, Bailure S.,Mahadevan, Kittapa M.,Hulikal, Vijaykumar
experimental part, p. 158 - 165 (2009/04/07)
A simple protocol was established to synthesize 2,3-dialkyl indoles and various tetrahydrocarbazoles via Fischer indole synthesis. This method uses ceric ammonium nitrate as a catalyst for the Fischer indole synthesis with substituted phenyl hydrazine hydrochlorides and 2-butanone, phenyl propanal, and cyclohexanone. This process is a practical synthetic method for the preparation of various 2,3-disubstituted alkyl indoles and tetrahydrocarbazoles. Copyright Taylor & Francis Group, LLC.
Bismuth nitrate promoted fischer indole synthesis: A simple and convenient approach for the synthesis of alkyl indoles
Sudhakara, Aralihalli,Jayadevappa, Honnali,Kumar, Hosanagara N.H.,Mahadevan, Kittappa M.
scheme or table, p. 159 - 164 (2010/04/23)
A novel one-pot fisher indole synthesis approach has been developed by using bismuth nitrate as a catalyst. Yields around 90-95% were obtained after reaction in methanol at reflux temperature in 20-40 min. Apart from the mild reaction conditions of the process and its excellent results, the simplicity of product isolation and the possibility to recycle the bismuth nitrate offers a significant advantage.
The regiospecific Fischer indole reaction in choline chloride· 2ZnCl2 with product isolation by direct sublimation from the ionic liquid
Morales, Raul Calderon,Tambyrajah, Vasuki,Jenkins, Paul R.,Davies, David L.,Abbott, Andrew P.
, p. 158 - 159 (2007/10/03)
The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride·2ZnCl2; exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.
