99-67-2Relevant articles and documents
Amemiya et al.
, p. 289,294 (1977)
A 2 - (2-allyl) pentene-4-acid methyl ester preparation method (by machine translation)
-
, (2017/03/14)
The invention relates to a machine intermediate 2 - (2-allyl) pentene-4-acid methyl ester preparation method, the preparation method is as follows: step 1) malonic acid ring (inferior) of potassium hydroxide in isopropyl acetate under alkaline conditions by PEG-400 catalytic and 3-polybromide propylene reaction produce compound 1 ; step 2) compound 1 under alkaline conditions in the sodium hydroxide of hydrolyzed to generate β-b acid compound 2 ; step 3) β-b acid compound 2 is heated and a single carboxyl the carboxyl group lives 3 ; step 4) single carboxyl compound 3 is obtained by reacting the methyl ester of the methyl esterification of compound 4 ; step 5) methyl ester compound 4 under alkaline conditions in and again LDA 3-polybromide propylene reaction produce the target compound 5. In the method for preparing the raw materials of the malonic acid ring a (sub) and isopropyl acetate 3-polybromide propylene, low cost, small synthetic process step, the operation is simple, convenient extraction and purification, the yield can reach 80% or more. (by machine translation)
Use of ethyl (benzothiazol-2-ylsulfonyl)acetate for malonic ester-type syntheses of carboxylic acids and esters
Hussein, Waleed M.,McGeary, Ross P.
, p. 1222 - 1227 (2014/10/16)
A new methodology for the synthesis of substituted carboxylic acids is described. Alkylation of either ethyl (benzothiazol-2-ylsulfonyl)acetate or ethyl 2-(benzothiazol-2-ylsulfonyl)propionate was achieved with alkyl halides and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in dichloromethane solution. These products were then desulfinated and hydrolysed in one-pot under mild conditions to give substituted acetic acids in good-to-excellent yields.