989-23-1Relevant articles and documents
Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility
Yang, Yun,Wang, Xinhui,Zhu, Qihua,Gong, Guoqing,Luo, Danmeng,Jiang, Aidou,Yang, Liyan,Xu, Yungen
, p. 1851 - 1855 (2014)
A novel series of water-soluble derivatives of limonin were synthesized by introducing various tertiary amines onto the C (7)-position of limonin. Ten target compounds were characterized and screened for their anti-inflammatory and analgesic activity in v
Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity
Furiassi, Lucia,Hergenrother, Paul J.,Tonogai, Emily J.
supporting information, p. 16119 - 16128 (2021/06/14)
Structurally complex natural products have been a fruitful source for the discovery and development of new drugs. In an effort to construct a compound collection populated by architecturally complex members with unique scaffolds, we have used the natural
Limonin - 7 - amino derivatives, its manufacturing method and medical use
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Paragraph 0019; 0106; 0107; 0108, (2017/08/25)
The invention relates to the field of pharmaceutical chemistry and particularly relates to water-soluble limonin-7-amino derivatives (I) and (II) shown in the specification, and a preparation method and medicine application thereof. Pharmacological experiments prove that the compounds disclosed by the invention have the analgesic and anti-inflammatory effects and can be clinically used for relieving pain and inflammatory diseases.
