98769-84-7 Usage
Description
Reboxetine mesylate is a selective noradrenaline reuptake inhibitor and an antidepressant medication.
Uses
Used in Pharmaceutical Industry:
Reboxetine mesylate is used as a selective norepinephrine transport blocker for the treatment of depression and other mood disorders. It helps to increase the levels of norepinephrine in the brain, which can improve mood and alleviate symptoms of depression.
Used in Research:
Reboxetine mesylate hydrate is used in research settings to study its effects on the surge of dopamine in the cortex of mice brain, its anti-immobility effects on the behavior of mice, and its effects on the probabilistic reversal learning task in rodents. These studies help to further understand the mechanisms of action of Reboxetine mesylate and its potential applications in various neurological and psychiatric conditions.
Biochem/physiol Actions
Reboxetine?exhibits anti-depressant activity.
Check Digit Verification of cas no
The CAS Registry Mumber 98769-84-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,6 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 98769-84:
(7*9)+(6*8)+(5*7)+(4*6)+(3*9)+(2*8)+(1*4)=217
217 % 10 = 7
So 98769-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m0./s1
98769-84-7Relevant articles and documents
The use of environmental metrics to evaluate green chemistry improvements to the synthesis of (S,S)-reboxetine succinate
Assaf, Georges,Checksfield, Graham,Critcher, Doug,Dunn, Peter J.,Field, Stuart,Harris, Laurence J.,Howard, Roger M.,Scotney, Gemma,Scott, Adam,Mathew, Suju,Walker, Geoffrey M. H.,Wilder, Alexander
, p. 123 - 129 (2012/04/11)
The Pfizer Green Chemistry metrics program is described and exemplified with a case history involving the synthesis of (S,S)-reboxetine succinate. The initial route used a classical resolution approach and generated high levels of waste. This route was replaced by an enantiospecific synthesis which used Sharpless epoxidation chemistry, an enzymatic process to selectively protect a primary alcohol and a new efficient method of chiral morpholine construction as key steps. These improvements reduced the levels of waste produced by the synthesis by more than 90%. Detailed metrics starting from a common starting material (trans-cinnamyl alcohol) for all routes of synthesis are presented.
Configurational studies on 2-[α-(2-ethoxyphenoxy)benzyl]morpholine FCE 20124
Melloni,Della Torre,Lazzari,et al.
, p. 1393 - 1399 (2007/10/02)
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