98769-82-5 Usage
Description
Reboxetine Methanesulfonate is a pharmaceutical compound that functions as a selective norepinephrine reuptake inhibitor (NRI), primarily used for the treatment of depression and attention-deficit hyperactivity disorder (ADHD). It operates by increasing norepinephrine levels in the brain, which aids in mood regulation and attention. The water-soluble methanesulfonate salt form enhances its administration and absorption in the body. Reboxetine Methanesulfonate has been approved in several countries and is recognized as an effective alternative for patients who do not respond to other antidepressants or ADHD medications. It should be administered under medical supervision due to potential side effects and contraindications.
Used in Pharmaceutical Industry:
Reboxetine Methanesulfonate is used as an antidepressant medication for treating depression and attention-deficit hyperactivity disorder (ADHD) due to its ability to selectively inhibit the reuptake of norepinephrine, thereby increasing its levels in the brain and improving mood and attention regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 98769-82-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,6 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 98769-82:
(7*9)+(6*8)+(5*7)+(4*6)+(3*9)+(2*8)+(1*2)=215
215 % 10 = 5
So 98769-82-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m0./s1
98769-82-5Relevant articles and documents
The use of environmental metrics to evaluate green chemistry improvements to the synthesis of (S,S)-reboxetine succinate
Assaf, Georges,Checksfield, Graham,Critcher, Doug,Dunn, Peter J.,Field, Stuart,Harris, Laurence J.,Howard, Roger M.,Scotney, Gemma,Scott, Adam,Mathew, Suju,Walker, Geoffrey M. H.,Wilder, Alexander
, p. 123 - 129 (2012/04/11)
The Pfizer Green Chemistry metrics program is described and exemplified with a case history involving the synthesis of (S,S)-reboxetine succinate. The initial route used a classical resolution approach and generated high levels of waste. This route was replaced by an enantiospecific synthesis which used Sharpless epoxidation chemistry, an enzymatic process to selectively protect a primary alcohol and a new efficient method of chiral morpholine construction as key steps. These improvements reduced the levels of waste produced by the synthesis by more than 90%. Detailed metrics starting from a common starting material (trans-cinnamyl alcohol) for all routes of synthesis are presented.
Configurational studies on 2-[α-(2-ethoxyphenoxy)benzyl]morpholine FCE 20124
Melloni,Della Torre,Lazzari,et al.
, p. 1393 - 1399 (2007/10/02)
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